Recombinant Mouse Elf3 Protein, Myc/DDK-tagged

• Cat.No.: Elf3-2797M
• Product Overview: Purified recombinant protein of mouse full-length E74-like factor 3 (Elf3), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 42.5 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Elf3 E74-like factor 3 [ Mus musculus (house mouse) ]
• Official Symbol: Elf3
• Synonyms: ELF3; E74-like factor 3; ETS-related transcription factor Elf-3; epithelial-restricted with serine box; epithelium-restricted Ets protein ESX; epithelium-specific Ets transcription factor 1; ESX; jen; ESE-1
• Gene ID: 13710
• mRNA Refseq: NM_007921
• Protein Refseq: NP_031947
• UniProt ID: Q3UPW2