Recombinant Mouse Eps15 Protein, MYC/DDK-tagged

• Cat.No.: Eps15-965M
• Product Overview: Purified recombinant protein of full-length mouse epidermal growth factor receptor pathway substrate 15 (Eps15), with C-terminal MYC/DDK tag, was expressed in HEK293T cells.

Specification

• Description: Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.
• Source: HEK293T
• Species: Mouse
• Tag: MYC/DDK
• Molecular Mass: 64.8 kDa
• Purity: >80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 µg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Eps15 epidermal growth factor receptor pathway substrate 15 [ Mus musculus (house mouse) ]
• Official Symbol: Eps15
• Synonyms: Eps15 epidermal; growth factor receptor pathway substrate 15; 2410112D09Rik; epidermal growth factor receptor substrate 15; epidermal growth factor pathway substrate 15; protein AF-1p
• Gene ID: 13858
• mRNA Refseq: NM_001159964
• Protein Refseq: NP_001153436
• UniProt ID: P42567