Recombinant Mouse Eps15 Protein, MYC/DDK-tagged Eps15-965M

Recombinant Mouse Eps15 Protein, MYC/DDK-tagged

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Recombinant Mouse Eps15 Protein, MYC/DDK-tagged

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Cat.No. : Eps15-965M
Product Overview : Purified recombinant protein of full-length mouse epidermal growth factor receptor pathway substrate 15 (Eps15), with C-terminal MYC/DDK tag, was expressed in HEK293T cells.
Description : Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.
Source : HEK293T
Species : Mouse
Tag : MYC/DDK
Molecular Mass : 64.8 kDa
Purity : >80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 µg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Eps15 epidermal growth factor receptor pathway substrate 15 [ Mus musculus (house mouse) ]
Official Symbol : Eps15
Synonyms : Eps15 epidermal; growth factor receptor pathway substrate 15; 2410112D09Rik; epidermal growth factor receptor substrate 15; epidermal growth factor pathway substrate 15; protein AF-1p
Gene ID : 13858
mRNA Refseq : NM_001159964
Protein Refseq : NP_001153436
UniProt ID : P42567

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