Recombinant Mouse F13a1 Protein, Myc/DDK-tagged

• Cat.No.: F13a1-2900M
• Product Overview: Purified recombinant protein of mouse full-length coagulation factor XIII, A1 subunit (F13a1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: This gene encodes subunit A of the coagulation factor XIII that catalyzes the final step of the blood coagulation pathway. The encoded protein associates with subunit B to form a heterotetrameric proenzyme that undergoes thrombin-mediated proteolysis to generate active factor XIIIa. The transglutaminase activity of factor XIIIa is required for the calcium-dependent crosslinking of fibrin, leading to the formation of a clot. Mice lacking the encoded protein display impaired reproduction and reduced survival due to bleeding episodes, hematothorax, hematoperitoneum and subcutaneous hemorrhage. Additionally, mice lacking the encoded protein exhibit impaired wound healing and inadequate healing of myocardial infarction. Alternative splicing results in multiple transcript variants.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 83.2 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: F13a1 coagulation factor XIII, A1 subunit [ Mus musculus (house mouse) ]
• Official Symbol: F13a1
• Synonyms: F13A1; coagulation factor XIII, A1 subunit; coagulation factor XIII A chain; Factor XIIIA; coagulation factor XIIIa; transglutaminase A chain; coagulation factor XIII, alpha subunit; protein-glutamine gamma-glutamyltransferase A chain; F13a; AI462306; 1200014I03Rik
• Gene ID: 74145
• mRNA Refseq: NM_001166391
• Protein Refseq: NP_001159863
• UniProt ID: Q8BH61