Recombinant Mouse FBXW10 Protein (701-1030 aa), His-SUMO-tagged

• Cat.No.: FBXW10-2132M
• Product Overview: Recombinant Mouse FBXW10 Protein (701-1030 aa) is produced by E. coli expression system. This protein is fused with a 6xHis-SUMO tag at the N-terminal. Protein Description: Partial.

Specification

• Description: Probable substrate-recognition component of a SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Overexpression is leading to degradation of CBX5 and CBX1 (By similarity).
• Source: E. coli
• Species: Mouse
• Tag: His-SUMO
• Form: Tris-based buffer,50% glycerol
• Molecular Mass: 53.2 kDa
• Protein length: 701-1030 aa
• AA Sequence: VKWQYSSDKNKVKKSKDKEEEREET SLGDEHSRSTIQGHSLKDSVSSKQE FSKSRVHLKQTKNLSSDDMETPVGE VSHPLQKLWKVPMTPDRFLLTISAL QQAHNSEEFAYPHRPRPQVIDAWGP SIPYPRKVLSLKGKSVQHAVDQLRS SNLPTGVRQTNIPLEIQKLQPNLKK SLHSPRVQATVPQPSLIRPKVSDSL RGDEHLTSSIDGTMRRAGPLTSMQV IKPNRMLAPRGGTATLSPKKERPRF YTTLDPLRMNTGFMLMTVKEEKEFA EAKMKEYEASVSTKEVDPGKASKAA WIRKIKGLPIDNFMKEGKTAAPELG QNVFI
• Purity: > 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA with reconstitution instruction is sent along with the products.

Gene Information

• Gene Name: Fbxw10 F-box and WD-40 domain protein 10 [ Mus musculus (house mouse) ]
• Official Symbol: FBXW10
• Synonyms: HREP; Fbw10; SM25H2; SM2SH2
• Gene ID: 213980
• UniProt ID: Q5SUS0