Recombinant Mouse Fgd1 Protein, Myc/DDK-tagged

• Cat.No.: Fgd1-2990M
• Product Overview: Purified recombinant protein of mouse full-length FYVE, RhoGEF and PH domain containing 1 (Fgd1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: This gene encodes a member of family of Rho-specific guanine nucleotide exchange factors. Rho-specific guanine nucleotide exchange factors catalyze the exchange of GDP for GTP and activate small GTPases, which function as molecular switches in signaling. This protein specifically binds cell division cycle 42, a Rho (Ras homology) GTPase. Investigations in mouse suggest that this protein is important for skeletal mineralization and for regulating the actin cytoskeleton. In humans, mutations in this gene are associated with faciogenital dysplasia, also known as Aarskog-Scott syndrome.
• Molecular Mass: 106.8 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Fgd1 FYVE, RhoGEF and PH domain containing 1 [ Mus musculus (house mouse) ]
• Official Symbol: Fgd1
• Synonyms: FGD1; FYVE, RhoGEF and PH domain containing 1; FYVE, RhoGEF and PH domain-containing protein 1; rho/Rac GEF; faciogenital dysplasia homolog; faciogenital dysplasia 1 protein homolog; zinc finger FYVE domain-containing protein 3; rho/Rac guanine nucleotide exchange factor FGD1; ZFYVE3
• Gene ID: 14163
• mRNA Refseq: NM_008001
• Protein Refseq: NP_032027
• UniProt ID: P52734