Recombinant Mouse Fgfr2 Protein, Myc/DDK-tagged

PRODUCTS

Home / Products / Recombinant Proteins / Recombinant Mouse Fgfr2 Protein, Myc/DDK-tagged

Recombinant Mouse Fgfr2 Protein, Myc/DDK-tagged

Fgfr2 Related Products

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.

Cat.No. : Fgfr2-3002M
Product Overview : Purified recombinant protein of mouse full-length fibroblast growth factor receptor 2 (cDNA clone MGC:102519 IMAGE:5349249), complete cds, with C-terminal MYC/DDK tag, expressed in HEK293T cells.
Description : Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 156.5 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Fgfr2 fibroblast growth factor receptor 2 [ Mus musculus (house mouse) ]
Official Symbol : Fgfr2
Synonyms : Fgfr2; fibroblast growth factor receptor 2; Bek; svs; Fgfr; KGFR; Fgfr-; Fgfr7; Fgfr-2; Fgfr-7; Fgfr2b; KGFRTr; AU043015; AW556123; fibroblast growth factor receptor 2; keratinocyte growth factor receptor; EC 2.7.10.1
Gene ID : 14183
mRNA Refseq : NM_010207
Protein Refseq : NP_034337
UniProt ID : P21803

Online Inquiry


  • Note: There will be extra charge for optional service!
  • Verification Code Please review Creative BioMart's privacy policy for more information

Optional Service: Optional requirements on this protein

Other Requirements:

Apply For A Coupon

$50 OFF Your First Purchase

Apply For a Coupon

Enter your email here to subscribe.

creative biomart inc.

Easy access to products and services you need from our library via powerful searching tools.

Follow Us

Copyright © 2007 – 2021 Creative BioMart. All Rights Reserved. Terms and Conditions | Privacy Policy