Recombinant Mouse GAD2 Protein, His-tagged

• Cat.No.: GAD2-28M
• Product Overview: Recombinant Mouse GAD2 Protein, fused to His-tag, was expressed in E. coli.

Specification

• Description: Predicted to enable glutamate binding activity; glutamate decarboxylase activity; and pyridoxal phosphate binding activity. Predicted to be involved in glutamate decarboxylation to succinate. Predicted to act upstream of or within neurotransmitter biosynthetic process. Located in axon; cytoplasm; and synapse. Is expressed in several structures, including genitourinary system; gut; heart; nervous system; and sensory organ. Used to study epilepsy and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in gestational diabetes; schizophrenia; and type 1 diabetes mellitus. Orthologous to human GAD2 (glutamate decarboxylase 2).
• Source: E. coli
• Species: Mouse
• Tag: His
• Form: 50mM Tris, 300mM NaCl, 0.05% SKL, pH 8.0.
• Molecular Mass: 67 kDa
• AA Sequence: MGSSHHHHHHSSGLVPRGSHMASPG SGFWSFGSEDGSADPENPGTARAWC QVAQKFTGGIGNKLCALLYGDSGKP AEGGGSVTSRAATGKVACTCDQKPC NCPKGDVNYAFLHATDLLPACDGER PTLAFLQDVMNILLQYVVKSFDRST KVIDFHYPNELLQEYNWELADQPQN LEEILTHCQTTLKYAIKTGHPRYFN QLSTGLDMVGLAADWLTSTANTNMF TYEIAPVFVLLEYVTLKKMREIIGW PGGSGDGIFSPGGAISNMYAMLIAR YKMFPEVKEKGMAAVPRLIAFTSEH SHFSLKKGAAALGIGTDSVILIKCD ERGKMIPSDLERRILEVKQKGFVPF LVSATAGTTVYGAFDPLLAVADICK KYKIWMHVDAAWGGGLLMSRKHKWK LSGVERANSVTWNPHKMMGVPLQCS ALLVREEGLMQSCNQMHASYLFQQD KHYDLSYDTGDKALQCGRHVDVFKL WLMWRAKGTTGFEAHIDKCLELAEY LYTIIKNREGYEMVFDGKPQHTNVC FWFVPPSLRTLEDNEERMSRLSKVA PVIKARMMEYGTTMVSYQPLGDKVN FFRMVISNPAATHQDIDFLIEEIER LGQDL
• Endotoxin: ＜1EU/ug by LAL.
• Purity: >90%
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Concentration: 0.32 mg/ml

Gene Information

• Gene Name: Gad2 glutamic acid decarboxylase 2 [ Mus musculus (house mouse) ]
• Official Symbol: GAD2
• Synonyms: GAD65; Gad-2; GAD(65); 6330404F12Rik
• Gene ID: 14417
• mRNA Refseq: NM_008078
• Protein Refseq: NP_032104
• UniProt ID: P48320