Active Recombinant Mouse Gdf15 Protein, Fc-tagged

• Cat.No.: Gdf15-01M
• Product Overview: The extracellular domain of mouse GDF15 (aa 189-303) is fused to the N-terminus of the Fc region of mouse IgG2a expressed in HEK293.

Specification

• Description: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The protein is expressed in a broad range of cell types, acts as a pleiotropic cytokine and is involved in the stress response program of cells after cellular injury. Increased protein levels are associated with disease states such as tissue hypoxia, inflammation, acute injury and oxidative stress. Mice lacking a functional copy of this gene exhibit progressive loss of motor neurons, and more rapid blood clot formation.
• Source: HEK293
• Species: Mouse
• Tag: Fc
• Bio-activity: Measured by its binding ability in a functional ELISA.
• Endotoxin: < 0.06 EU/μg purified protein.
• Purity: ≥ 98% (SDS-PAGE)
• Stability: Stable for at least 1 year after receipt when stored at -20 centigrade.
  Working aliquots are stable for up to 3 months when stored at -20 centigrade.
• Storage: Short Term Storage: +4 centigrade
  Long Term Storage: -20 centigrade
• Storage Buffer: Lyophilized from 0.2 μm-filtered solution in PBS.
• Reconstitution: Reconstitute at 100 μg/mL in sterile PBS.
• Shipping: BLUE ICE

Gene Information

• Gene Name: Gdf15 growth differentiation factor 15 [ Mus musculus (house mouse) ]
• Official Symbol: Gdf15
• Synonyms: Gdf15; growth differentiation factor 15; NAG; SBF; MIC-; MIC-1; NAG-1; growth/differentiation factor 15; macrophage inhibiting cytokine-1; macrophage inhibitory cytokine 1
• Gene ID: 23886
• mRNA Refseq: NM_011819
• Protein Refseq: NP_035949
• UniProt ID: Q9Z0J7