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Active Recombinant Mouse IFNB1 Protein, Fc-tagged

Cat.No. : IFNB1-892M
Product Overview : Recombinant extracellular domain of mouse IFNB1 (P01575) (Met 1-Asn 182) was fused with the Fc region of human IgG1 at the C-terminus.
  • Specification
  • Gene Information
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Source : HEK293
Species : Mouse
Tag : Fc
Predicted N Terminal : Ile 22
Form : Lyophilized from sterile PBS, pH 7.4, 5%~8% trehalose and mannitol.
Bio-activity : Measured in antiviral assays using L929 cells infected with vesicular stomatitisvirus (VSV). The ED50 for this effect is typically 10-50 pg/mL.
Molecular Mass : The secreted recombinant mouse IFNB1/Fc is a disulfide-linked homodimer. The reduced monomer comprises 402 amino acids and has a calculated molecular mass of 46.7 kDa. As a result of glycosylation, the apparent molecular mass of rmIFNB1/Fc monomer is approximately 58 kDa in SDS-PAGE under reducing conditions.
Endotoxin : < 1.0 EU per μg of the protein as determined by the LAL method.
Purity : >92 % as determined by SDS-PAGE.
Stability : Samples are stable for up to twelve months from date of receipt at -70ºC.
Storage : Store it under sterile conditions at -20ºC~-70ºC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.25 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Gene Name : Ifnb1 interferon beta 1, fibroblast [ Mus musculus ]
Official Symbol : IFNB1
Synonyms : IFNB1; interferon beta 1, fibroblast; interferon beta; Ifb; IFNB; IFN-beta;
Gene ID : 15977
mRNA Refseq : NM_010510
Protein Refseq : NP_034640
MIM :
UniProt ID :
Pathway : Chagas disease (American trypanosomiasis), organism-specific biosystem; Chagas disease (American trypanosomiasis), conserved biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved
Function : cytokine activity; cytokine receptor binding; transcription corepressor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any contraindications for IFNB1 treatment? 01/26/2021

IFNB1 is generally not recommended for individuals with a history of hypersensitivity to interferons or other components of the drug. It should be used with caution in patients with certain pre-existing medical conditions.

Can IFNB1 be used in cancer treatment? 02/11/2020

IFNB1 is being investigated for its potential role in cancer treatment due to its immunomodulatory effects. Clinical trials are ongoing to evaluate its efficacy in various types of cancer.

What are the potential side effects of IFNB1 treatment? 06/27/2019

Common side effects include flu-like symptoms, injection site reactions, and changes in blood cell counts. Serious side effects are rare but can include liver problems and allergic reactions.

How is IFNB1 administered in clinical settings? 06/04/2019

IFNB1 is often administered through subcutaneous or intramuscular injections. The frequency and dosage depend on the specific condition being treated.

In what other conditions is IFNB1 protein clinically utilized? 10/09/2016

IFNB1 is also used in the treatment of certain viral infections, such as hepatitis B and C. It has antiviral properties that can inhibit viral replication.

Customer Reviews (3)

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Reviews
06/24/2021

    The manufacturer not only ensures the provision of superior protein but also aids researchers with their solid technical support, offering the necessary resources to optimize experimental protocols.

    08/29/2020

      the IFNB1 protein offers numerous advantages for researchers conducting trials due to its high quality and stability.

      11/08/2018

        manufacturers or suppliers of proteins can play a crucial role in supporting researchers during trials.

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