Recombinant Mouse Ifnl2 Protein Ifnl2-145M

Recombinant Mouse Ifnl2 Protein

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Recombinant Mouse Ifnl2 Protein

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Cat.No. : Ifnl2-145M
Product Overview : Purified recombinant protein of Mouse interleukin 28A (Il28a) without tag was expressed in E.coli.
Description : Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression
Source : E. coli
Species : Mouse
Bio-activity : Determined by its ability to activate STAT following receptor-ligand interaction.
Molecular Mass : 19.8 kDa
AA Sequence : MDPVPRATRL PVEAKDCHIA QFKSLSPKEL QAFKKAKDAI EKRLLEKDMR CSSHLISRAW DLKQLQVQER PKALQAEVAL TLKVWENMTD SALATILGQP LHTLSHIHSQ LQTCTQLQAT AEPKPPSRRL SRWLHRLQEA QSKETPGCLE DSVTSNLFRL LTRDLKCVAS GDQCV
Endotoxin : Endotoxin level is < 0.1 ng/µg of protein (< 1 EU/µg)
Purity : >95%, as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for at least 6 months from date of receipt under proper storage and handling conditions.
Storage : Store at -80 centigrade.
Storage Buffer : Lyophilized from a 0.2 µM filtered solution of 20mM phosphate buffer,100mM NaCl, pH 7.2
Reconstitution : Resuspend the protein in the desired concentration in proper buffer.
Figure :

Gene Name : Ifnl2 interferon lambda 2 [ Mus musculus (house mouse) ]
Official Symbol : Ifnl2
Synonyms : Ifnl2; interferon lambda 2; Il28a; IL-28A; EG330496; interferon lambda-2; IFN-lambda-2; IFN-lambda2; interferon-lambda2; interleukin-28A
Gene ID : 330496
mRNA Refseq : NM_001024673
Protein Refseq : NP_001019844
UniProt ID : Q4VK74

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