Active Recombinant Mouse Il2 Protein
Cat.No. : | Il2-104M |
Product Overview : | Purified recombinant protein of Mouse interleukin 2 (Il2) without tag was expressed in E.coli. |
- Specification
- Gene Information
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Description : | Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells. |
Source : | E. coli |
Species : | Mouse |
Bio-activity : | The ED50 as determined by the dose dependent stimulation of murine CTLL-2 cells is > 0.2 ng/ml, corresponding to a specific activity of > 5 x 10^6 units/mg. |
Molecular Mass : | 17.2 kDa |
AA Sequence : | PTSSSTSSSTAEAQQQQQQQQQQQQ HLEQLLMDLQELLSRMENYRNLKLP RMLTFKFYLPKQATELKDLQCLEDE LGPLRHVLDLTQSKSFQLEDAENFI SNIRVTVVKLKGSDNTFECQFDDES ATVVDFLRRWIAFCQSIISTSPQ |
Endotoxin : | Endotoxin level is < 0.1 ng/µg of protein (< 1 EU/µg) |
Purity : | >95%, as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for at least 6 months from date of receipt under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. |
Storage Buffer : | Lyophilized from a 0.2 µM filtered solution of 20mM phosphate buffer,100mM NaCl, pH 7.2 |
Reconstitution : | Resuspend the protein in the desired concentration in proper buffer. |
Gene Name : | Il2 interleukin 2 [ Mus musculus (house mouse) ] |
Official Symbol : | Il2 |
Synonyms : | Il2; interleukin 2; Il-2; interleukin-2; T-cell growth factor; TCGF |
Gene ID : | 16183 |
mRNA Refseq : | NM_008366 |
Protein Refseq : | NP_032392 |
UniProt ID : | P04351 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionIL2 promotes the formation of memory T-cells.
IL2 has a pro-tumorigenic role in the tumor microenvironment.
IL2 synergizes with IL-12 in a mixed cytokine environment.
IL2 upregulates the expression of PD-1 checkpoint inhibitors.
IL2 is rapidly internalized by activated T-cells.
IL2 induces M1 macrophage polarization.
IL2 increases blood-brain barrier permeability.
IL2's affinity for its receptor decreases under hypoxic conditions.
IL2's bioactivity is enhanced by glycosylation.
IL2 promotes the differentiation of Th17 cells.
Customer Reviews (3)
Write a reviewPotent in T-cell activation.
Suitable for cytokine assays.
High stability.
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