Recombinant Mouse IL21 Receptor Protein, Fc-tagged
| Cat.No. : | Il21r-448M |
| Product Overview : | Recombinant Mouse Il21r (AAL82636.1) (Met1-Pro236) was expressed with the Fc region of human IgG1 at the C-terminus. |
- Specification
- Gene Information
- Related Products
| Description : | Interleukin-21 receptor, also known as IL-21 receptor, IL-21R, Novel interleukin receptor, IL21R and NILR, is a single-pass type I membrane protein which belongs to the type I cytokine receptor family and Type 4 subfamily. Interleukin-21 (IL-21) belongs to a family of cytokines that bind to a composite receptor consisting of a private receptor (IL-21R) and the common cytokine receptor gamma chain ( gamma(C) ). The IL-21R is discovered as a novel member of the class-I-cytokine-receptor family and is selectively expressed in lymphoid tissues. IL-21R shows strong sequence homologies to the interleukin-4 receptor alpha chain gene (IL-4RA). The WSXWS motif of IL-21R appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box 1 motif of IL-21R is required for JAK interaction and / or activation. The IL-21R is widely distributed on lympho-haematopoietic cells and IL21 impacts a number of cell types, including CD8+ memory T cells, NK cells and subsets of CD4 memory T cells. Increased IL21 production is characteristic of certain autoimmune diseases and is likely to contribute to autoantibody production as well as pathological features of autoimmune disease. The critical role of IL21 in promoting humoral immune responses makes it an important f centigradeus of potential therapeutic interventions in conditions characterised by overproduction of pathogenic autoantibodies. |
| Source : | HEK293 |
| Species : | Mouse |
| Tag : | Fc |
| Predicted N Terminal : | Cys 20 |
| Form : | Lyophilized from sterile PBS, pH 7.4. Normally 5 %- 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. |
| Molecular Mass : | The recombinant mouse Il21r consists 455 amino acids and predicts a molecular mass of 51.6 kDa. |
| Protein length : | Met1-Pro236 |
| Endotoxin : | < 1.0 EU per μg protein as determined by the LAL method. |
| Purity : | > 90 % as determined by SDS-PAGE. |
| Storage : | Samples are stable for up to twelve months from date of receipt at-70 centigrade. Store it under sterile conditions at-20 centigrade to-80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
| Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents. |
| Gene Name : | Il21r interleukin 21 receptor [ Mus musculus ] |
| Official Symbol : | Il21r |
| Synonyms : | IL21R; interleukin 21 receptor; interleukin-21 receptor; NR8; IL-21R; LR-beta; IL-21 receptor; lymphocyte receptor beta; novel cytokine receptor 8; novel interleukin receptor; NILR; |
| Gene ID : | 60504 |
| mRNA Refseq : | NM_021887 |
| Protein Refseq : | NP_068687 |
Products Types
| ◆ Recombinant Protein | ||
| Il21r-10582M | Recombinant Mouse Il21r Protein, His (Fc)-Avi-tagged | +Inquiry |
| IL21R-326H | Recombinant Human IL21R Protein, Fc-tagged | +Inquiry |
| Il21r-176M | Recombinant Mouse IL21R Protein (ECD), His-tagged(C-ter) | +Inquiry |
| IL21R-325H | Recombinant Human IL21R Protein, His-tagged | +Inquiry |
| Il21r-02M | Active Recombinant Mouse Il21r Protein, hIgG/His-tagged | +Inquiry |
| ◆ Lysates | ||
| IL21R-001CCL | Recombinant Cynomolgus IL21R cell lysate | +Inquiry |
| IL21R-2019HCL | Recombinant Human IL21R cell lysate | +Inquiry |
| IL21R-1442RCL | Recombinant Rat IL21R cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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