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Recombinant Mouse IL23A & IL12B Heterodimer Protein, His-tagged
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Cat.No. : | IL23A&IL12B-336M Optional Service: Optional requirements on this protein |
Product Overview : | Recombinant Mouse IL23A & IL12B Heterodimer Protein, His-tagged is expressed from human 293 cells (HEK293). It contains AA Val 22 - Ala 196 (IL23A) & Met 23 - Ser 335 (IL12B) (Accession # Q9EQ14 (IL23A) & NP_032378 (IL12B)). Predicted N-terminus: His (IL23A) & Met 23 (IL12B). Mouse IL-23 alpha & IL-12 beta Heterodimer Protein, produced by co-expression of IL-23 alpha and IL-12 beta, has a calculated MW of 20.5 kDa (IL-23 alpha) and 35.8 kDa (IL-12 beta). Subunit IL-23 alpha is fused with a polyhistidine tag at the N-terminus and subunit IL-12 beta contains no tag. The predicted N-terminus is His (IL23A) & Met 23 (IL12B). The reducing (R) protein migrates as 21 kDa (IL-23 alpha) and 45-50 kDa (IL-12 beta) respectively due to glycosylation. |
Source : | HEK293 |
Species : | Mouse |
Tag : | His |
Form : | Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization. |
Bio-activity : | Recombinant Mouse IL23A & IL12B Heterodimer Protein, His-tagged at 10 μg/mL (100 μL/well) can bind Human IL23R with a linear range of 0.078-1.25 μg/mL (Routinely tested). Recombinant Mouse IL23A & IL12B Heterodimer Protein, His-tagged stimulates secretion of IL-17 by mouse spleen cells. The ED50 for this effect is 0.008-0.0134ng/ml (Routinely tested). |
Molecular Mass : | 20.5 kDa (IL23A) & 35.8 kDa (IL12B) |
Protein length : | Val 22 - Ala 196 (IL23A) & Met 23 - Ser 335 (IL12B) |
Endotoxin : | Less than 1.0 EU per μg by the LAL method. |
Purity : | >90% as determined by SDS-PAGE. |
Notes : | Please avoid repeated freeze-thaw cycles. |
Stability : | No activity loss is observed after storage at: 4-8 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 mg/ml. Centrifuge the vial at 4 centigrade before opening to recover the entire contents. |
Figure : |
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Gene Name : | Il23a interleukin 23, alpha subunit p19 [ Mus musculus ] & Il12b interleukin 12b [ Mus musculus ] |
Official Symbol : | IL23A & IL12B |
Synonyms : | IL23A; interleukin 23, alpha subunit p19; IL-23-A; IL-23p19; p19; IL-23; & IL12B; interleukin 12b; CLMF p40; IL-12 p40; IL-12 subunit p40; p40; Il-12b; Il12p40; Il-12p40; |
Gene ID : | 83430 & 16160 |
mRNA Refseq : | NM_031252 & NM_008352 |
Protein Refseq : | NP_112542 & NP_032378 |
◆ Recombinant Protein
IL23A&IL12B-334H | Recombinant Human IL23A & IL12B Heterodimer Protein, His & Avi-tagged, Biotinylated | +Inquiry |
IL23A&IL12B-333H | Recombinant Human IL23A & IL12B Heterodimer Protein, His-tagged | +Inquiry |
IL23A&IL12B-335HM | Recombinant Human IL23A & Mouse IL12B Heterodimer Protein, His-tagged | +Inquiry |
IL23A&IL12B-332H | Recombinant Human IL23A&IL12B(Ile23-Ser328&Ala21-Pro189) Protein, C-Fc-tagged | +Inquiry |
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IL10IL10RAIL10RBIL11IL11RAIl11ra1IL12IL12AIL12BIL12RB1IL13IL13RA1IL13RA2IL15IL15RAIL16IL17AIL17BIl17cIL17DIl17fIL17RAIL17RDIL18IL18BPIL18R1IL18RAPIl19Il1aIl1bIL1F10IL1R1Il1r2IL1RAPIL1RAPL1IL1RAPL2IL1RL1IL1RL2Il1rnIL2Il20IL20RAIL21IL21RIL22IL22BPIL22RA1IL22RA2IL23AIL24Il25IL27IL27RAIL28AIl28bIL29IL2RAIL2RBIl2rgIL3IL31IL32Il33Il34IL3RAIL4IL4RIl4raIl5IL5RAIl6IL6RIl6raIL6STIl7IL7RIL8IL9IL36AIl12rb2IL17RBIL23RIL26IL31RAIL36BIL36GIL36RNIL37IL9RIL17RCIL17REIL28RAIL4I1IL20RBIL17RELIl11ra2IL27bIL7RAIl23a&Il12b
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