Recombinant Mouse IL3RA Protein, hIgG-His-tagged

• Cat.No.: IL3RA-03M
• Product Overview: Recombinant Mouse IL3RA Protein, fused to hIgG-His-tag, was expressed in Insect Cell.

Specification

• Description: Enables interleukin-3 binding activity and interleukin-3 receptor activity. Acts upstream of or within interleukin-3-mediated signaling pathway; monocyte differentiation; and regulation of cell growth. Located in membrane. Is expressed in several structures, including cardiovascular system mesenchyme; dorsal aorta; early conceptus; genitourinary system; and umbilical or vitelline vessel. Orthologous to human IL3RA (interleukin 3 receptor subunit alpha).
• Source: Insect Cell
• Species: Mouse
• Tag: His&Fc
• Form: Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 30% glycerol.
• Molecular Mass: 61.5 kDa
• Protein length: 17-331aa
• AA Sequence: SDLAAVREAP PTAVTTPIQN LHIDPAHYTL SWDPAPGADI TTGAFCRKGR DIFVWADPGL ARCSFQSLSL CHVTNFTVFL GKDRAVAGSI QFPPDDDGDH EAAAQDLRCW VHEGQLSCQW ERGPKATGDV HYRMFWRDVR LGPAHNRECP HYHSLDVNTA GPAPHGGHEG CTLDLDTVLG STPNSPDLVP QVTITVNGSG RAGPVPCMDN TVDLQRAEVL APPTLTVECN GSEAHARWVA RNRFHHGLLG YTLQVNQSSR SEPQEYNVSI PHFWVPNAGA ISFRVKSRSE VYPRKLSSWS EAWGLVCPPE VMPVK
• Endotoxin: < 1 EU per 1ug of protein (determined by LAL method).
• Purity: > 90%
• Applications: SDS-PAGE
• Notes: For research use only. This product is not intended or approved for human, diagnostics or veterinary use.
• Storage: Can be stored at 2 centigrade to 8 centigrade for 1 week. For long term storage, aliquot and store at -20 centigrade to -80 centigrade. Avoid repeated freezing and thawing cycles.
• Concentration: 0.25 mg/ml

Gene Information

• Gene Name: Il3ra interleukin 3 receptor, alpha chain [ Mus musculus (house mouse) ]
• Official Symbol: IL3RA
• Synonyms: Interleukin-3 receptor subunit alpha; IL-3R subunit alpha; IL-3R-alpha,nterleukin-3 receptor class II alpha chain; L3RA; CD123; hIL-3Ra; IL3R; IL3RAY; IL3RX; IL3RY; CDW123; SUT-1
• Gene ID: 16188
• mRNA Refseq: NM_008369
• Protein Refseq: NP_032395
• UniProt ID: P26952

Reviews

07/24/2022

In special environment, good stability.

05/25/2022

Good crystallization property and good effect.

06/29/2021

Has the expected biological activity, such as enzyme activity and receptor binding activity, and so on.

Q&As

Can Il3ra be personalized?

The feasibility of personalized therapy depends on the specific disease type and patient situation, and more research is needed to determine the application of personalized therapy to Il3ra.

Does Il3ra have clinical application prospects? What are the prospects?

Il3ra has certain promise in clinical application, especially in the treatment of immune-related diseases.

What is the action mechanism of Il3ra?

Regulates the proliferation and differentiation of immune cells by binding to its interacting cytokine IL-3, and plays a role in regulating the function of the immune system.

How is the clinical trial of Il3ra progressing?

Clinical trials of recombinant Il3ra have been conducted in different disease areas. At present, some early trials show its potential in the treatment of certain diseases, but more research is needed to verify its efficacy and safety.

What is the specific effect of Il3ra on the immune system?

The Il3ra can regulate the proliferation and differentiation of different types of immune cells in the immune system, thus affecting the function of the immune system.

Does Il3ra have side effects?

Il3ra is generally well tolerated, but some minor side effects such as headache and nausea may occur. Serious side effects are rare.