Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Mouse Ing2 Protein, Myc/DDK-tagged

Cat.No. : Ing2-3536M
Product Overview : Purified recombinant protein of mouse full-length inhibitor of growth family, member 2 (Ing2), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
  • Specification
  • Gene Information
  • Related Products
Description : Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs).
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 33 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Ing2 inhibitor of growth family, member 2 [ Mus musculus (house mouse) ]
Official Symbol : Ing2
Synonyms : ING2; inhibitor of growth family, member 2; inhibitor of growth protein 2; inhibitor of growth 1-like protein; Ing1l; Ing2b; P33ING2; 2810011M06Rik
Gene ID : 69260
mRNA Refseq : NM_023503
Protein Refseq : NP_075992
UniProt ID : Q9ESK4

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (7)

Ask a question
What were the myocardial expression levels of specific proteins influenced by chronic AngⅡ infusion and Ing2 silencing? 10/08/2022

Chronic AngⅡ infusion increased myocardial expression levels of Ac-p53(Lys382) and p-p53(Ser15), and Ing2 silencing prior to AngⅡ infusion reduced the increase in Ac-p53(Lys382) without affecting p53(Ser15) expression.

What are the expression levels of Ing2 mRNA and protein in mice with chronic Ang Ⅱ infusion? 10/16/2021

Ing2 mRNA and protein levels were significantly higher in mice with chronic Ang Ⅱ infusion compared to saline-infused mice.

What is the overall conclusion drawn from this study? 11/20/2020

The conclusion is that Ing2 silencing can inhibit AngⅡ-induced cardiac remodeling and dysfunction in mice by reducing p53 acetylation.

What was the impact of Ing2 silencing on AngⅡ-induced cardiac function decline? 10/01/2020

Ing2 silencing significantly alleviated AngⅡ-induced cardiac function decline, as evidenced by reduced LVEDD and LVESD and increased LVEF and LVFS.

How does the regulation of p53 acetylation relate to cardiac remodeling and dysfunction? 09/17/2019

The study suggests that the reduction of p53 acetylation by Ing2 silencing contributes to the prevention of cardiac remodeling and dysfunction in response to chronic AngⅡ infusion.

How did chronic infusion of AngⅡ affect left ventricular parameters in mice? 07/05/2019

Chronic AngⅡ infusion led to increased left ventricular end-systolic diameter (LVESD) and left ventricular end-diastolic diameter (LVEDD) and reduced left ventricular ejection fraction (LVEF) and left ventricular fractional shortening (LVFS) in the mice.

In addition to cardiac function, what other aspects did Ing2 silencing affect in mice with chronic AngⅡ infusion? 04/27/2018

Ing2 silencing improved myocardial mitochondrial damage, reduced myocardial hypertrophy and fibrosis, and inhibited cardiomyocyte apoptosis induced by chronic AngⅡ infusion.

Customer Reviews (3)

Write a review
Reviews
07/30/2022

    Feel free to continue expanding your list by adding these reviews to your Excel sheet.

    07/11/2019

       Consistently achieving specific outcomes validated the pivotal role of the product in our research studies.

      05/08/2016

        The product's unique attributes propelled our research to innovative heights.

        Ask a Question for All Ing2 Products

        Required fields are marked with *

        My Review for All Ing2 Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends