Recombinant Mouse Ing2 Protein, Myc/DDK-tagged
Cat.No. : | Ing2-3536M |
Product Overview : | Purified recombinant protein of mouse full-length inhibitor of growth family, member 2 (Ing2), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
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- Gene Information
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Description : | Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs). |
Source : | HEK293T |
Species : | Mouse |
Tag : | Myc/DDK |
Molecular Mass : | 33 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Ing2 inhibitor of growth family, member 2 [ Mus musculus (house mouse) ] |
Official Symbol : | Ing2 |
Synonyms : | ING2; inhibitor of growth family, member 2; inhibitor of growth protein 2; inhibitor of growth 1-like protein; Ing1l; Ing2b; P33ING2; 2810011M06Rik |
Gene ID : | 69260 |
mRNA Refseq : | NM_023503 |
Protein Refseq : | NP_075992 |
UniProt ID : | Q9ESK4 |
Products Types
◆ Recombinant Protein | ||
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ING2-4543M | Recombinant Mouse ING2 Protein, His (Fc)-Avi-tagged | +Inquiry |
ING2-8208M | Recombinant Mouse ING2 Protein | +Inquiry |
ING2-308H | Recombinant Human inhibitor of growth family, member 2, His-tagged | +Inquiry |
◆ Lysates | ||
ING2-5208HCL | Recombinant Human ING2 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionChronic AngⅡ infusion increased myocardial expression levels of Ac-p53(Lys382) and p-p53(Ser15), and Ing2 silencing prior to AngⅡ infusion reduced the increase in Ac-p53(Lys382) without affecting p53(Ser15) expression.
Ing2 mRNA and protein levels were significantly higher in mice with chronic Ang Ⅱ infusion compared to saline-infused mice.
The conclusion is that Ing2 silencing can inhibit AngⅡ-induced cardiac remodeling and dysfunction in mice by reducing p53 acetylation.
Ing2 silencing significantly alleviated AngⅡ-induced cardiac function decline, as evidenced by reduced LVEDD and LVESD and increased LVEF and LVFS.
The study suggests that the reduction of p53 acetylation by Ing2 silencing contributes to the prevention of cardiac remodeling and dysfunction in response to chronic AngⅡ infusion.
Chronic AngⅡ infusion led to increased left ventricular end-systolic diameter (LVESD) and left ventricular end-diastolic diameter (LVEDD) and reduced left ventricular ejection fraction (LVEF) and left ventricular fractional shortening (LVFS) in the mice.
Ing2 silencing improved myocardial mitochondrial damage, reduced myocardial hypertrophy and fibrosis, and inhibited cardiomyocyte apoptosis induced by chronic AngⅡ infusion.
Customer Reviews (3)
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Consistently achieving specific outcomes validated the pivotal role of the product in our research studies.
The product's unique attributes propelled our research to innovative heights.
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