Recombinant Mouse Inpp4b Protein, Myc/DDK-tagged

• Cat.No.: Inpp4b-3545M
• Product Overview: Purified recombinant protein of mouse full-length inositol polyphosphate-4-phosphatase, type II (Inpp4b), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-bisphosphate. Plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3,4-bisphosphate in membrane ruffles. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 104.5 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Inpp4b inositol polyphosphate-4-phosphatase, type II [ Mus musculus (house mouse) ]
• Official Symbol: Inpp4b
• Synonyms: INPP4B; inositol polyphosphate-4-phosphatase, type II; type II inositol 3,4-bisphosphate 4-phosphatase; type II inositol-3,4-bisphosphate 4-phosphatase; inositol polyphosphate 4-phosphatase type II beta isoform; E130107I17Rik
• Gene ID: 234515
• mRNA Refseq: NM_001024617
• Protein Refseq: NP_001019788
• UniProt ID: Q6P1Y8