Recombinant Mouse Ireb2 Protein, Myc/DDK-tagged

• Cat.No.: Ireb2-3571M
• Product Overview: Purified recombinant protein of mouse full-length iron responsive element binding protein 2 (Ireb2), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 105.4 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Ireb2 iron responsive element binding protein 2 [ Mus musculus (house mouse) ]
• Official Symbol: Ireb2
• Synonyms: IREB2; iron responsive element binding protein 2; iron-responsive element-binding protein 2; IRE-BP 2; iron regulatory protein 2; Irp2; D9Ertd85e; DKFZp564D1164
• Gene ID: 64602
• mRNA Refseq: NM_022655
• Protein Refseq: NP_073146
• UniProt ID: Q811J3