Recombinant Mouse Knstrn Protein, Myc/DDK-tagged

• Cat.No.: Knstrn-2437M
• Product Overview: Purified recombinant protein of mouse full-length DNA segment, Chr 2, ERATO Doi 750, expressed (cDNA clone MGC:30961 IMAGE:4021550), complete cds, with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase. Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments. Required for kinetochore oscillations and dynamics of microtubule plus-ends during live cell mitosis, possibly by forming a link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 26.5 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Knstrn kinetochore-localized astrin/SPAG5 binding [ Mus musculus (house mouse) ]
• Official Symbol: Knstrn
• Synonyms: Knstrn; kinetochore-localized astrin/SPAG5 binding; SKAP; C15orf23; Traf4af1; D2Ertd750; D2Ertd750e; 1700025D04Rik; small kinetochore-associated protein; TRAF4 associated factor 1 homolog; TRAF4-associated factor 1; kinastrin; kinetochore-localized astrin-binding protein; kinetochore-localized astrin/SPAG5-binding protein; putative TRAF4-associated factor 1
• Gene ID: 51944
• mRNA Refseq: NM_026412
• Protein Refseq: NP_080688
• UniProt ID: Q9D9Z1