Recombinant Mouse Lamtor2 Protein, Myc/DDK-tagged

• Cat.No.: Lamtor2-3750M
• Product Overview: Purified recombinant protein of mouse full-length late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 (Lamtor2), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 13.9 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Lamtor2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 [ Mus musculus (house mouse) ]
• Official Symbol: Lamtor2
• Synonyms: LAMTOR2; late endosomal/lysosomal adaptor, MAPK and MTOR activator 2; ragulator complex protein LAMTOR2; endosomal adaptor protein p14; roadblock domain containing 3; roadblock domain-containing protein 3; late endosomal/lysosomal MP1 interacting protein; late endosomal/lysosomal Mp1-interacting protein; mitogen activated protein binding protein interacting protein; mitogen-activated protein binding protein interacting protein; mitogen-activated protein-binding protein-interacting protein; late endosomal/lysosomal adaptor and MAPK and MTOR activator 2; P14; Rab25; Robld3; Mapbpip; AL022628; 2010111E04Rik
• Gene ID: 83409
• mRNA Refseq: NM_031248
• Protein Refseq: NP_112538
• UniProt ID: Q9JHS3