Recombinant Mouse Mad1l1 Protein, Myc/DDK-tagged

• Cat.No.: Mad1l1-3894M
• Product Overview: Purified recombinant protein of mouse full-length MAD1 mitotic arrest deficient 1-like 1 (Mad1l1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Forms a heterotetrameric complex with the closed conformation form of MAD2L1 (C-MAD2) at unattached kinetochores during prometaphase, recruits an open conformation of MAD2L1 (O-MAD2) and promotes the conversion of O-MAD2 to C-MAD2, which ensures mitotic checkpoint signaling.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 83.5 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Mad1l1 MAD1 mitotic arrest deficient 1-like 1 [ Mus musculus (house mouse) ]
• Official Symbol: Mad1l1
• Synonyms: MAD1L1; MAD1 mitotic arrest deficient 1-like 1; mitotic spindle assembly checkpoint protein MAD1; MAD1-like protein 1; mitotic arrest deficient 1-like 1; mitotic arrest deficient 1-like protein 1; Mad1; AI173502; AW550425
• Gene ID: 17120
• mRNA Refseq: NM_010752
• Protein Refseq: NP_034882
• UniProt ID: Q9WTX8