Recombinant Mouse Map2k4 Protein, Myc/DDK-tagged Map2k4-3923M

Recombinant Mouse Map2k4 Protein, Myc/DDK-tagged

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Recombinant Mouse Map2k4 Protein, Myc/DDK-tagged

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Cat.No. : Map2k4-3923M Optional Service: Optional requirements on this protein
Product Overview : Purified recombinant protein of mouse full-length mitogen activated protein kinase kinase 4 (cDNA clone MGC:36532 IMAGE:3962163), complete cds, with C-terminal MYC/DDK tag, expressed in HEK293T cells.
Description : Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to proinflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 32.2 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Map2k4 mitogen-activated protein kinase kinase 4 [ Mus musculus (house mouse) ]
Official Symbol : Map2k4
Synonyms : Map2k4; mitogen-activated protein kinase kinase 4; Sek; Ser; JNKK; MEK4; MKK4; Sek1; JNKK1; Serk1; PRKMK4; MAPKK 4; dual specificity mitogen-activated protein kinase kinase 4; C-JUN N-terminal kinase kinase 1; JNK kinase 1; JNK-activating kinase 1; MAP kinase kinase 4; MAPK/ERK kinase 4; SAPK/ERK kinase 1; SAPK/Erk/kinase 1; mitogen activated protein kinase kinase 4, variant 1; EC 2.7.12.2
Gene ID : 26398
mRNA Refseq : NM_009157
Protein Refseq : NP_033183
UniProt ID : P47809
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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