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Recombinant Mouse Mob1b Protein, Myc/DDK-tagged

Cat.No. : Mob1b-4105M
Product Overview : Purified recombinant protein of mouse full-length MOB kinase activator 1B (Mob1b), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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  • Gene Information
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Description : Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 25.5 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Mob1b MOB kinase activator 1B [ Mus musculus (house mouse) ]
Official Symbol : Mob1b
Synonyms : MOB1B; MOB kinase activator 1B; mob1 homolog 1A; mps one binder kinase activator-like 1A; MOB1, Mps One Binder kinase activator-like 1A; Mobkl1a; AU015450; B230364F10; 1110003E08Rik; MGC129510; MGC129511
Gene ID : 68473
mRNA Refseq : NM_026735
Protein Refseq : NP_081011
UniProt ID : Q8BPB0

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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