Recombinant Mouse Mpz Protein, Myc/DDK-tagged

• Cat.No.: Mpz-4131M
• Product Overview: Purified recombinant protein of mouse full-length myelin protein zero (Mpz), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: This gene is specifically expressed in Schwann cells of the peripheral nervous system and encodes a type I transmembrane glycoprotein that is a major structural protein of the peripheral myelin sheath. The encoded protein contains a large hydrophobic extracellular domain and a smaller basic intracellular domain, which are essential for the formation and stabilization of the multilamellar structure of the compact myelin. Mutations in the orthologous gene in human are associated with myelinating neuropathies. A recent study showed that two isoforms are produced from the same mRNA by use of alternative in-frame translation termination codons via a stop codon readthrough mechanism. Alternatively spliced transcript variants have also been found for this gene.
• Molecular Mass: 28.1 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Mpz myelin protein zero [ Mus musculus (house mouse) ]
• Official Symbol: Mpz
• Synonyms: MPZ; myelin protein zero; myelin protein P0; myelin peripheral protein; P0; Mpp; P-zero
• Gene ID: 17528
• mRNA Refseq: NM_008623
• Protein Refseq: NP_032649
• UniProt ID: P27573