Recombinant Mouse MSLN Protein (298-600 aa), His-SUMO-tagged

• Cat.No.: MSLN-669M
• Product Overview: Recombinant Mouse MSLN Protein (298-600 aa) is produced by E. coli expression system. This protein is fused with a 6xHis-SUMO tag at the N-terminal. Protein Description: Partial.

Specification

• Description: Mbrane-anchored forms may play a role in cellular adhesion.
• Source: E. coli
• Species: Mouse
• Tag: His&SUMO
• Form: Tris-based buffer, 50% glycerol
• Molecular Mass: 50.1 kDa
• Protein length: 298-600 aa
• AA Sequence: DAEQKACPPGKEPYKVDEDLIFYQN WELEACVDGTMLARQMDLVNEIPFT YEQLSIFKHKLDKTYPQGYPESLIQ QLGHFFRYVSPEDIHQWNVTSPDTV KTLLKVSKGQKMNAQAIALVACYLR GGGQLDEDMVKALGDIPLSYLCDFS PQDLHSVPSSVMWLVGPQDLDKCSQ RHLGLLYQKACSAFQNVSGLEYFEK IKTFLGGASVKDLRALSQHNVSMDI ATFKRLQVDSLVGLSVAEVQKLLGP NIVDLKTEEDKSPVRDWLFRQHQKD LDRLGLGLQGGIPNGYLVLDFNVRE AFS
• Purity: > 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA with concentration instruction is sent along with the products.

Gene Information

• Gene Name: Msln mesothelin [ Mus musculus ]
• Official Symbol: MSLN
• Synonyms: MSLN; mesothelin; MPF
• Gene ID: 56047
• mRNA Refseq: NM_018857
• Protein Refseq: NP_061345
• UniProt ID: Q61468

Reviews

05/22/2022

Very satisfied, great product.

03/06/2022

Product is high-quality.

09/30/2021

Excellent for experiments, reliable.

Q&As

What is the primary role of MSLN in normal tissues?

MSLN is normally expressed in mesothelial cells, playing a role in cell adhesion.

How is MSLN expression altered in cancerous cells?

In cancer, MSLN expression is significantly upregulated.

In which types of cancer is MSLN overexpressed?

MSLN is overexpressed in mesothelioma, ovarian, and pancreatic cancers.

Are there any therapeutic strategies targeting MSLN in cancer treatment?

Therapies targeting MSLN include antibody-drug conjugates and CAR-T cell therapies.

How can MSLN levels be detected and measured in clinical settings?

MSLN levels can be assessed through immunohistochemistry and serum biomarker tests.

What is the prognostic significance of MSLN overexpression in cancer patients?

MSLN overexpression is often associated with poor prognosis in cancer patients.

How does MSLN contribute to cancer progression and metastasis?

MSLN promotes tumor cell proliferation, invasion, and resistance to apoptosis.