Recombinant Mouse MUSK Protein, His-SUMO/MYC-tagged

• Cat.No.: MUSK-1288M
• Product Overview: Recombinant Mouse MUSK Protein (22-494aa) was expressed in E. coli with N-terminal His-SUMO tag and C-terminal MYC tag.

Specification

• Description: This gene encodes a member of the protein tyrosine kinase family. The encoded protein is a type 1 receptor-like protein located in muscle membrane that is activated by the heparan sulfate proteoglycan agrin released by nerve cells. The encoded protein activates signaling cascades responsible for multiple aspects of motor neuron and muscle development, including organization of the postsynaptic membrane, synaptic gene transcription, patterning of skeletal muscle, anchoring of acetylcholinesterase, and guidance of motor axons. Alternatively spliced transcript variants encoding different isoforms have been described.
• Source: E. coli
• Species: Mouse
• Tag: His-SUMO/MYC
• Form: Tris-based buffer, 50% glycerol.
• Molecular Mass: 69.3 kDa
• AA Sequence: EKLPKAPVITTPLETVDALVEEVAT FMCAVESYPQPEISWTRNKILIKLF DTRYSIRENGQLLTILSVEDSDDGI YCCIANNGVGGAVESCGALQVKMKP KITRPPINVKIIEGLKAVLPCTTMG NPKPSVSWIKGDNALRENSRIAVLE SGSLRIHNVQKEDAGQYRCVAKNSL GTAYSKLVKLEVEVFARILRAPESH NVTFGSFVTLRCTAIGIPVPTISWI ENGNAVSSGSIQESVKDRVIDSRLQ LFITKPGLYTCIATNKHGEKFSTAK AAATVSIAEWSKSQKDSQGYCAQYR GEVCDAVLAKDALVFFNTSYRDPED AQELLIHTAWNELKAVSPLCRPAAE ALLCNHLFQECSPGVVPTPMPICRE YCLAVKELFCAKEWQAMEGKAHRGL YRSGMHLLPVPECSKLPSMHRDPTA CTRLPYLDYKKENITTFPSITS
• Purity: Greater than 90% as determined by SDS-PAGE.
• Storage: The shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.

Gene Information

• Gene Name: Musk muscle, skeletal, receptor tyrosine kinase [ Mus musculus (house mouse) ]
• Official Symbol: Musk
• Synonyms: Mlk; Mdk4; Nsk1; Nsk2; Nsk3
• Gene ID: 18198
• mRNA Refseq: NM_001037127.2
• Protein Refseq: NP_001032204.2
• UniProt ID: Q61006

Reviews

11/20/2022

The MUSK protein's high quality, stellar technical support, and compatibility with diverse experimental approaches make it an optimal choice for meeting my research needs.

09/01/2017

Its usage in these techniques is highly praised by scientists worldwide, attesting to its effectiveness and significance in advancing scientific knowledge and understanding.

01/25/2017

Its ability to consistently provide accurate and reliable results makes it an invaluable tool for quantifying and detecting specific targets in biological samples.

Q&As

How is MUSK protein targeted in the treatment of autoimmune myasthenia gravis?

In autoimmune myasthenia gravis, immunosuppressive therapies and acetylcholinesterase inhibitors are commonly used to manage symptoms, and some treatments specifically target the immune response against MUSK.

Can MUSK protein abnormalities be detected early in life?

Yes, genetic testing and other diagnostic measures can identify MUSK protein abnormalities early in life, enabling prompt intervention and management.

Are there diagnostic tests for MUSK-related disorders?

Yes, diagnostic tests such as genetic testing and antibody assays can be employed to identify MUSK-related disorders.

How does MUSK protein contribute to muscle regeneration?

MUSK protein plays a role in signaling pathways that contribute to muscle regeneration, making it an important factor in tissue repair.

Can MUSK protein be a target for gene therapy?

Yes, gene therapy approaches aimed at restoring normal MUSK function are being explored as potential treatments for MUSK-related disorders.