Recombinant Mouse Mxra8 Protein, Myc/DDK-tagged

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Recombinant Mouse Mxra8 Protein, Myc/DDK-tagged

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Cat.No. : Mxra8-4233M
Product Overview : Purified recombinant protein of mouse full-length matrix-remodelling associated 8 (Mxra8), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
Description : Transmembrane protein which can modulate activity of various signaling pathways, probably via binding to integrin ITGAV:ITGB3. Mediates heterophilic cell-cell interactions in vitro. Inhibits osteoclastogenesis downstream of TNFSF11/RANKL and CSF1, where it may function by attenuating signaling via integrin ITGB3 and MAP kinase p38. Plays a role in cartilage formation where it promotes proliferation and maturation of growth plate chondrocytes. Stimulates formation of primary cilia in chondrocytes. Enhances expression of genes involved in the hedgehog signaling pathway in chondrocytes, including the hedgehog signaling molecule IHH; may also promote signaling via the PTHLH/PTHrP pathway. Plays a role in angiogenesis where it suppresses migration of endothelial cells and also promotes their apoptosis. Inhibits VEGF-induced activation of AKT and p38 MAP kinase in endothelial cells. Also inhibits VTN (vitronectin)-mediated integrin ITGAV:ITGB3 signaling and activation of PTK2/FAK. May play a role in the maturation and maintenance of the blood-brain barrier.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 50.2 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Mxra8 matrix-remodelling associated 8 [ Mus musculus (house mouse) ]
Official Symbol : Mxra8
Synonyms : Mxra8; matrix-remodelling associated 8; Asp3; Dicam; AI131686; 1200013A08Rik; 1700095D18Rik; matrix remodeling-associated protein 8; adipocyte-specific protein 3; dual Ig domain containing cell adhesion molecule; limitrin; matrix-remodeling-associated protein 8
Gene ID : 74761
mRNA Refseq : NM_024263
Protein Refseq : NP_077225
UniProt ID : Q9DBV4

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