Recombinant Mouse Neurotrophic Tyrosine Kinase, Receptor, Type 3, His-tagged

• Cat.No.: Ntrk3-908M
• Product Overview: A DNA sequence encoding the extracellular domain of mouse TrkC (NP_032772.3) (Met 1-Thr 429) was expressed, with a C-terminal polyhistidine tag.

Specification

• Species: Mouse
• Source: Mouse
• Tag: His
• Protein Length: 1-429 a.a.
• Description: Ntrk3 is a single-pass type I membrane protein. Ntrk3 belongs to the protein kinase superfamily and insulin receptor subfamily. Mouse Ntrk3 is a 825 amino acid (aa) protein and is widely expressed but mainly in nervous tissue. It contains two Ig-like C2-type (immunoglobulin-like) domains, one LRR (leucine-rich) repeats and one protein kinase domain. Ntrk3 is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway.
• Form: Lyophilized from sterile PBS, pH 7.4. Normally 5%-8% trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
• Purity: > 95 % as determined by SDS-PAGE
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
• Stability: Samples are stable for up to twelve months from date of receipt at -70°C.
• Predicted N terminal: Cys 32
• Molecular Mass: The secreted recombinant mouse TrkC comprises 409 amino acids and has a calculated molecular mass of 46.1 kDa. As a result of glycosylation, the recombinant protein migrates as an approximately 100-110 kDa band in SDS-PAGE under reducing conditions.
• Storage: Store it under sterile conditions at -70°C upon receiving. Recommend to aliquot the protein into smaller quantities for optimal storage. Avoid repeated freeze-thaw cycles.

Gene Information

• Gene Name: Ntrk3 neurotrophic tyrosine kinase, receptor, type 3 [ Mus musculus ]
• Official Symbol: Ntrk3
• Synonyms: Ntrk3; neurotrophic tyrosine kinase, receptor, type 3; TrkC; AW125844; NT-3 growth factor receptor; trk-C; GP145-TrkC; OTTMUSP00000023300; OTTMUSP00000023301; trkC tyrosine kinase
• Gene ID: 18213
• mRNA Refseq: NM_008746
• Protein Refseq: NP_032772
• UniProt ID: Q6VNS1
• Chromosome Location: 7
• Pathway: Neurotrophin signaling pathway
• Function: ATP binding; kinase activity; neurotrophin receptor activity; nucleotide binding; protein binding; protein kinase activity; protein tyrosine kinase activity; receptor activity; transferase activity; transferase activity, transferring phosphorus-containing groups; transmembrane receptor protein tyrosine kinase activity