Recombinant Mouse Nkiras1 Protein, Myc/DDK-tagged

• Cat.No.: Nkiras1-4421M
• Product Overview: Purified recombinant protein of mouse full-length NFKB inhibitor interacting Ras-like protein 1 (Nkiras1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB.
• Molecular Mass: 21.7 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Nkiras1 NFKB inhibitor interacting Ras-like protein 1 [ Mus musculus (house mouse) ]
• Official Symbol: Nkiras1
• Synonyms: NKIRAS1; NFKB inhibitor interacting Ras-like protein 1; NF-kappa-B inhibitor-interacting Ras-like protein 1; kappa B-Ras protein 1; I-kappa-B-interacting Ras-like protein 1; KBRAS1; kappaB-Ras1; 2400004O09Rik
• Gene ID: 69721
• mRNA Refseq: NM_023526
• Protein Refseq: NP_076015
• UniProt ID: Q8CEC5