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Active Recombinant Mouse Notum Protein, His-tagged

Cat.No. : NOTUM-25M
Product Overview : Recombinant Mouse Notum (Ser88-Thr458, Cys337Ser)was expressed in mouse myeloma cell line with a C-terminal 6-His tag.
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  • Gene Information
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Source : Mammalian cells
Species : Mouse
Tag : His
Form : Lyophilized from a 0.2 μm filtered solution in PBS.
Bio-activity : Measured by its ability to inhibit Wnt induced TCF reporter activity in HEK293 human embryonic kidney cells. The ED50 for this effect is 0.2-1.2 μg/mL in the presence of 0.1 μg/mL of Recombinant Mouse Wnt-3a.
Molecular Mass : 39-46 kDa under reducing conditions.
Endotoxin : <0.10 EU per 1 μg of the protein by the LAL method.
Purity : >95% by SDS-PAGE
Storage : 12 months from date of receipt, -20 to -70 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
Reconstitution : Reconstitute at 100 μg/mL in PBS.
Gene Name : Notum notum pectinacetylesterase homolog (Drosophila) [ Mus musculus (house mouse) ]
Official Symbol : NOTUM
Synonyms : NOTUM; notum pectinacetylesterase homolog (Drosophila); protein notum homolog
Gene ID : 77583
mRNA Refseq : NM_175263.4
Protein Refseq : NP_780472.3
UniProt ID : Q8R116

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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In neurological disorders, how does NOTUM protein contribute to therapeutic interventions? 12/03/2022

NOTUM's role in Wnt signaling modulation has implications for neurodegenerative disorders, and targeting NOTUM may offer therapeutic avenues for conditions such as Alzheimer's disease.

How does NOTUM protein affect stem cell function? 10/17/2020

NOTUM is involved in the regulation of stem cell behavior through its influence on Wnt signaling, making it a target for manipulating stem cell activities.

Are there any ongoing clinical trials exploring NOTUM-targeted therapies? 08/03/2020

Several clinical trials are underway to investigate the safety and efficacy of NOTUM inhibitors in cancer patients, providing valuable insights into their clinical potential.

How does NOTUM protein influence tissue homeostasis? 01/31/2018

NOTUM's role in regulating Wnt signaling contributes to tissue homeostasis, and understanding this mechanism can provide insights into maintaining tissue health.

How can NOTUM protein be utilized in personalized medicine approaches? 04/27/2016

Understanding individual variations in NOTUM expression and activity may allow for personalized treatment strategies, tailoring interventions based on a patient's molecular profile.

Customer Reviews (3)

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Reviews
08/26/2021

    Its excellent performance in ELISA assays makes it a valuable tool in quantifying analytes in biological samples.

    11/09/2020

      Its reliability, specificity, and versatility make it an invaluable asset in studying and understanding complex biological systems.

      07/20/2020

        Its usage in ELISA and protein electron microscopy structure analysis has been reported to yield highly reproducible and interpretable results, providing valuable insights into the molecular mechanisms and biological processes under investigation.

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