Recombinant Mouse Pan2 Protein, MYC/DDK-tagged
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| Cat.No. : | Pan2-224M |
| Product Overview : | Purified recombinant protein of full-length mouse PAN2 poly(A) specific ribonuclease subunit (Pan2), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
| Description : | Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. Also acts as an important regulator of the HIF1A-mediated hypoxic response. Required for HIF1A mRNA stability independent of poly(A) tail length regulation. |
| Source : | HEK293T |
| Species : | Mouse |
| Tag : | MYC/DDK |
| Molecular Mass : | 135.3 kDa |
| Purity : | >80%, as determined by SDS-PAGE and Coomassie blue staining |
| Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Storage : | Store at -80 centigrade after receiving vials. |
| Concentration : | >50 ug/mL as determined by microplate BCA method |
| Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
| Gene Name : | Pan2 PAN2 poly(A) specific ribonuclease subunit [ Mus musculus (house mouse) ] |
| Official Symbol : | Pan2 |
| Synonyms : | Pan2; PAN2 poly(A) specific ribonuclease subunit; Usp52; AI047843; AW742773; mKIAA0710; 1200014O24Rik; PAN2-PAN3 deadenylation complex catalytic subunit Pan2; AN2 polyA specific ribonuclease subunit homolog; PAB-dependent poly(A)-specific ribonuclease subunit 2; PAB-dependent poly(A)-specific ribonuclease subunit PAN2; PAB1P-dependent poly(A)-nuclease; PAN deadenylation complex catalytic subunit 2; PAN2 polyA specific ribonuclease subunit homolog; inactive ubiquitin carboxyl-terminal hydrolase 52; poly(A)-nuclease deadenylation complex subunit 2; ubiquitin specific peptidase 52; ubiquitin specific protease 52; EC 3.1.13.4 |
| Gene ID : | 103135 |
| mRNA Refseq : | NM_133992 |
| Protein Refseq : | NP_598753 |
| UniProt ID : | Q8BGF7 |
◆ Recombinant Protein
| PAN2-12331M | Recombinant Mouse PAN2 Protein | +Inquiry |
| PAN2-2165C | Recombinant Chicken PAN2 | +Inquiry |
| PAN2-4265R | Recombinant Rat PAN2 Protein | +Inquiry |
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◆ Lysates
| PAN2-3446HCL | Recombinant Human PAN2 293 Cell Lysate | +Inquiry |
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