Recombinant Mouse Pcsk1n Protein, Myc/DDK-tagged

• Cat.No.: Pcsk1n-4720M
• Product Overview: Purified recombinant protein of mouse full-length proprotein convertase subtilisin/kexin type 1 inhibitor (Pcsk1n), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: May function in the control of the neuroendocrine secretory pathway. Proposed be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 87 kDa form but not the autocatalytically derived 66 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. May control the intracellular timing of PCSK1 rather than its total level of activity. The function of the processed secreted peptides is not known.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 27.3 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Pcsk1n proprotein convertase subtilisin/kexin type 1 inhibitor [ Mus musculus (house mouse) ]
• Official Symbol: Pcsk1n
• Synonyms: PCSK1N; proprotein convertase subtilisin/kexin type 1 inhibitor; proSAAS; IA-4; big SAAS; pro-SAAS; little LEN; big PEN LEN; little SAAS; basic protein IA-4; pancreas protein 3; proprotein convertase 1 inhibitor; granin-like neuroendocrine peptide; protein serine alanine alanine serine; KEP; PEN; Pan3; SAAS; bLEN; lLEN; PEN19; PEN20; SAASCT; AI848336; MGC19107
• Gene ID: 30052
• mRNA Refseq: NM_013892
• Protein Refseq: NP_038920
• UniProt ID: Q9QXV0