Recombinant Mouse Pde9a Protein, Myc/DDK-tagged

• Cat.No.: Pde9a-4753M
• Product Overview: Purified recombinant protein of mouse full-length phosphodiesterase 9A (Pde9a), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP. Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein (Probable). In brain, involved in cognitive function, such as learning and long-term memory.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 61.6 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Pde9a phosphodiesterase 9A [ Mus musculus (house mouse) ]
• Official Symbol: Pde9a
• Synonyms: PDE9A; phosphodiesterase 9A; high affinity cGMP-specific 3,5-cyclic phosphodiesterase 9A; PDE9A1
• Gene ID: 18585
• mRNA Refseq: NM_008804
• Protein Refseq: NP_032830
• UniProt ID: O70628