Recombinant Mouse Phlpp1 Protein, Myc/DDK-tagged
Cat.No. : | Phlpp1-4842M |
Product Overview : | Purified recombinant protein of mouse full-length PH domain and leucine rich repeat protein phosphatase 1 (Phlpp1), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
- Specification
- Gene Information
- Related Products
Description : | Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT2 and AKT3, 'Ser-660' of PRKCB and 'Ser-657' of PRKCA. Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons. Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and suppression of tumor growth. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis. Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation. Inhibits cancer cell proliferation and may act as a tumor suppressor. Dephosphorylates RAF1 inhibiting its kinase activity. May act as a negative regulator of K-Ras signaling in membrane rafts. Involved in the hippocampus-dependent long-term memory formation Involved in circadian control by regulating the consolidation of circadian periodicity after resetting Involved in development and function of regulatory T-cells |
Source : | HEK293T |
Species : | Mouse |
Tag : | Myc/DDK |
Molecular Mass : | 182.8 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Phlpp1 PH domain and leucine rich repeat protein phosphatase 1 [ Mus musculus (house mouse) ] |
Official Symbol : | Phlpp1 |
Synonyms : | PHLPP1; PH domain and leucine rich repeat protein phosphatase 1; PH domain leucine-rich repeat-containing protein phosphatase 1; PH domain-containing family E member 1; suprachiasmatic nucleus circadian oscillatory protein; pleckstrin homology domain-containing family E member 1; pleckstrin homology domain containing, family E (with leucine rich repeats) member 1; SCOP; Phlpp; Plekhe1; AI836256; mKIAA0606 |
Gene ID : | 98432 |
mRNA Refseq : | NM_133821 |
Protein Refseq : | NP_598582 |
UniProt ID : | Q8CHE4 |
Products Types
◆ Recombinant Protein | ||
PHLPP1-1669H | Recombinant Human PHLPP1 Protein, His (Fc)-Avi-tagged | +Inquiry |
PHLPP1-4089R | Recombinant Rat PHLPP1 Protein, His (Fc)-Avi-tagged | +Inquiry |
PHLPP1-6707M | Recombinant Mouse PHLPP1 Protein, His (Fc)-Avi-tagged | +Inquiry |
PHLPP1-934H | Recombinant Human PHLPP1 | +Inquiry |
PHLPP1-107H | Recombinant Human PHLPP1 protein, GST-tagged | +Inquiry |
◆ Lysates | ||
PHLPP1-3218HCL | Recombinant Human PHLPP1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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