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Recombinant Mouse Pip4k2a Protein, Myc/DDK-tagged

Cat.No. : Pip4k2a-4873M
Product Overview : Purified recombinant protein of mouse full-length phosphatidylinositol-5-phosphate 4-kinase, type II, alpha (Pip4k2a), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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  • Gene Information
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Description : Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Has both ATP- and GTP-dependent kinase activities. May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size May negatively regulate insulin-stimulated glucose uptake by lowering the levels of PtdIns5P.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 46.2 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Pip4k2a phosphatidylinositol-5-phosphate 4-kinase, type II, alpha [ Mus musculus (house mouse) ]
Official Symbol : Pip4k2a
Synonyms : PIP4K2A; phosphatidylinositol-5-phosphate 4-kinase, type II, alpha; phosphatidylinositol-5-phosphate 4-kinase type-2 alpha; PIP4KII-alpha; PI(5)P 4-kinase type II alpha; diphosphoinositide kinase 2-alpha; ptdIns(5)P-4-kinase isoform 2-alpha; 1-phosphatidylinositol-5-phosphate 4-kinase 2-alpha; phosphatidylinositol-4-phosphate 5-kinase, type II, alpha; Pip5k2a; AW742916
Gene ID : 18718
mRNA Refseq : NM_008845
Protein Refseq : NP_032871
UniProt ID : O70172

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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