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Recombinant Mouse Psmd2 Protein, Myc/DDK-tagged

Cat.No. : Psmd2-5193M
Product Overview : Purified recombinant protein of mouse full-length proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 (Psmd2), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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Description : Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 100.2 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Psmd2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 [ Mus musculus (house mouse) ]
Official Symbol : Psmd2
Synonyms : PSMD2; proteasome (prosome, macropain) 26S subunit, non-ATPase, 2; 26S proteasome non-ATPase regulatory subunit 2; testis expressed gene 190; 26S proteasome subunit p97; 26S proteasome regulatory subunit S2; 26S proteasome regulatory subunit RPN1; Tex190; TEG-190; AA407121; 9430095H01Rik
Gene ID : 21762
mRNA Refseq : NM_134101
Protein Refseq : NP_598862
UniProt ID : Q8VDM4

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does PSMD2 contribute to cellular homeostasis? 10/05/2020

PSMD2 helps maintain cellular homeostasis by regulating the turnover of proteins, controlling their abundance and activity.

Can PSMD2 be a target for therapeutic interventions? 01/31/2020

Targeting components of the ubiquitin-proteasome system, including PSMD2, is explored for potential therapeutic interventions in certain diseases.

What is the primary function of PSMD2? 03/05/2019

PSMD2 is a subunit of the 26S proteasome, a cellular complex involved in protein degradation.

Are there diseases associated with PSMD2 dysfunction? 03/01/2018

Dysregulation of proteasomal function, including PSMD2, is implicated in various diseases, such as neurodegenerative disorders and cancer.

Is PSMD2 involved in protein quality control? 09/13/2017

Yes, PSMD2, as part of the 26S proteasome, contributes to protein quality control by degrading misfolded or damaged proteins.

In what cellular processes does PSMD2 play a role? 04/19/2017

PSMD2 plays a crucial role in the ubiquitin-proteasome system, participating in targeted protein degradation.

What is the subcellular location of PSMD2? 01/04/2016

PSMD2 is typically found in the nucleus and cytoplasm, reflecting its involvement in cellular protein degradation processes.

Customer Reviews (3)

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Reviews
02/25/2021

    The product's stability over extended periods was a significant advantage for our long-term research projects.

    01/05/2021

      Consistency in its performance over time made it a reliable resource for ongoing experiments.

      06/11/2019

        The absence of adverse effects on cells or organisms underscored the product's safety and suitability for biological research.

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