Recombinant Mouse Ptprb Protein, Myc/DDK-tagged

• Cat.No.: Ptprb-5244M
• Product Overview: Purified recombinant protein of mouse full-length protein tyrosine phosphatase, receptor type, B (Ptprb), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 224.9 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Ptprb protein tyrosine phosphatase, receptor type, B [ Mus musculus (house mouse) ]
• Official Symbol: Ptprb
• Synonyms: PTPRB; protein tyrosine phosphatase, receptor type, B; receptor-type tyrosine-protein phosphatase beta; R-PTP-beta; protein-tyrosine phosphatase beta; vascular endothelial protein tyrosine phosphatase; Ptpz; Rptpb; Veptp; VE-PTP; C130094E24; 3230402H02Rik
• Gene ID: 19263
• mRNA Refseq: NM_029928
• Protein Refseq: NP_084204
• UniProt ID: B2RU80