"PVRIG" Related Products


Recombinant Mouse PVRIG protein, Fc-tagged

Cat.No.: PVRIG-12M
Product Overview: The extracellular domain of mouse CD112R (aa 28-165) fused with the C-terminus to the Fc portion of human IgG1 was expressed in HEK 293 cells.
Description: CD112 (also called Nectin-2 or poliovirus receptor-related 2 protein) is a type I transmembrane glycoprotein and a member of the Ig gene superfamily (IGSF). CD112/Nectin-2 functions as an adhesion molecule involved in the formation of cell junctions and interactions with other Nectin-family molecules. Nectin-2 is a also a surface marker of some endothelial cells and regulates migration, proliferation and angiogenesis. CD112 functions as an immune checkpoint regulator by modulating T cell signaling, either as a costimulator of T cell function, or as a coinhibitor of T cells proliferation by binding to the receptors CD226 or TIGIT (T cell Ig and immunoreceptor tyrosine-based inhibitory motif (ITIM) domain), respectively. The binding of CD112 ligand to these receptors is weak compared to CD155. Recently, a new receptor of CD112, called CD112R or PVRIG (Poliovirus receptor-related immunoglobulin domain-containing protein) has been characterized, showing high affinity to CD112. CD112R is a new coinhibitory receptor of the PVR family for human T cells, inhibiting TCR-mediated signals upon binding to CD112/Nectin-2. CD112R is preferentially expressed in T lymphocytes and NK cells. Cancer cells evade immune responses as a result of an immunosuppressive tumor microenvironment and CD112R, by playing a role in the regulation of the immune system, could be a new attractive cancer immunotherapy target.
Source: HEK293 cells
Species: Mouse
Tag : Fc
Form: Lyophilized. Contains PBS.
Bio-activity: Binds to the ligand mouse CD112 (PVRL2, Nectin-2) with an EC50 of 5nM.
Molecular Mass: ~48-50 kDa (SDS-PAGE)
Endotoxin: <0.01EU/μg purified protein (LAL test)
Purity: >90% (SDS-PAGE)
Stability: Stable for at least 6 months after receipt when stored at -20 centigrade.
Storage: Short term store at +4 centigrade, store at -20 centigrade for long term storage.
Concentration: 0.1mg/mL after reconstitution.
Reconstitution: Reconstitute with 100 μL sterile water.
Handling: After reconstitution, prepare aliquots and store at -20 centigrade. Avoid freeze/thaw cycles. PBS containing at least 0.1% BSA should be used for further dilutions.
Gene Name: poliovirus receptor related immunoglobulin domain containing [ Mus musculus (house mouse) ]
Official Symbol: Pvrig
Synonyms: CD112 Receptor; Poliovirus Receptor-related Immunoglobulin Domain-containing Protein; Transmembrane Protein PVRIG
Gene ID: 102640920
mRNA Refseq: XM_011240963.2
Protein Refseq: XP_011239265.1
UniProt ID: A0A1B0GS01

Online Inquiry

Note: There will be extra charge for optional service!
Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information

Price does not include shipping and packaging costs.Request quote for final price.

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.