Recombinant Mouse Rab10 Protein, Myc/DDK-tagged
Cat.No. : | Rab10-5282M |
Product Overview : | Purified recombinant protein of mouse full-length RAB10, member RAS oncogene family (Rab10), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
- Specification
- Gene Information
- Related Products
- Download
Description : | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane. Regulates, for instance, SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane. In parallel, it regulates the transport of TLR4, a toll-like receptor to the plasma membrane and therefore may be important for innate immune response. Plays also a specific role in asymmetric protein transport to the plasma membrane. In neurons, it is involved in axonogenesis through regulation of vesicular membrane trafficking toward the axonal plasma membrane. In epithelial cells, it regulates transport from the Golgi to the basolateral membrane. May play a role in the basolateral recycling pathway and in phagosome maturation. May play a role in endoplasmic reticulum dynamics and morphology controlling tubulation along microtubules and tubules fusion. Together with LRRK2, RAB8A, and RILPL1, it regulates ciliogenesis. When phosphorylated by LRRK2 on Thr-73, it binds RILPL1 and inhibits ciliogenesis. |
Source : | HEK293T |
Species : | Mouse |
Tag : | Myc/DDK |
Molecular Mass : | 22.5 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Rab10 RAB10, member RAS oncogene family [ Mus musculus (house mouse) ] |
Official Symbol : | Rab10 |
Synonyms : | RAB10; RAB10, member RAS oncogene family; ras-related protein Rab-10; AW107754 |
Gene ID : | 19325 |
mRNA Refseq : | NM_016676 |
Protein Refseq : | NP_057885 |
UniProt ID : | P61027 |
Products Types
◆ Recombinant Protein | ||
RAB10-1823H | Recombinant Human RAB10 Protein, His (Fc)-Avi-tagged | +Inquiry |
RAB10-7335M | Recombinant Mouse RAB10 Protein, His (Fc)-Avi-tagged | +Inquiry |
RAB10-005H | Recombinant Human RAB10 Protein, MYC/DDK-tagged, C13 and N15-labeled | +Inquiry |
Rab10-3399M | Recombinant Mouse Rab10 protein, His-SUMO-tagged | +Inquiry |
RAB10-2771C | Recombinant Chicken RAB10 | +Inquiry |
◆ Lysates | ||
RAB10-2632HCL | Recombinant Human RAB10 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (8)
Ask a questionWe didn't check the phosphorylation status of our RAB10 proteins. But the following one expressed in HEK293 should be phosphorylated.
RAB10 aids in autophagy, maintaining cellular health by regulating the degradation and recycling of cell components.
RAB10 plays a crucial role in glucose uptake and metabolism, particularly in response to insulin.
RAB10 regulates cell signaling pathways, playing a role in intercellular communication and response to stimuli.
RAB10 is linked to neurodegenerative diseases, potentially influencing protein aggregation and neuronal function.
Variations in RAB10 can contribute to the development of diabetes and insulin resistance by affecting glucose metabolism.
RAB10 is key in directing vesicle trafficking, ensuring efficient transport and membrane dynamics within cells.
RAB10 impacts endocytosis and receptor trafficking, affecting cell surface receptor dynamics and signaling.
Customer Reviews (3)
Write a reviewReliable mass spectrometry analysis, pivotal for advancing our proteomics research.
Accurate protein structural analysis, indispensable for our investigations.
Swift and reliable protein sequencing, a key asset for our work.
Ask a Question for All Rab10 Products
Required fields are marked with *
My Review for All Rab10 Products
Required fields are marked with *
Inquiry Basket