Recombinant Mouse Rcc1 Protein, MYC/DDK-tagged

• Cat.No.: Rcc1-019M
• Product Overview: Purified recombinant protein of full-length mouse regulator of chromosome condensation 1 (Rcc1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nuclear import and mitosis. Contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and normal progress through mitosis. Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the release of cargo proteins from importins after nuclear import. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA.
• Source: HEK293T
• Species: Mouse
• Tag: MYC/DDK
• Molecular Mass: 44.9 kDa
• Purity: >80%, as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 ug/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Rcc1 regulator of chromosome condensation 1 [ Mus musculus (house mouse) ]
• Official Symbol: Rcc1
• Synonyms: Rcc1; regulator of chromosome condensation 1; Chc1; AI326872; 4931417M11Rik; regulator of chromosome condensation; chromosome condensation protein 1
• Gene ID: 100088
• mRNA Refseq: NM_133878
• Protein Refseq: NP_598639
• UniProt ID: Q8VE37