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Recombinant Mouse Rheb Protein, Myc/DDK-tagged

Cat.No. : Rheb-5504M
Product Overview : Purified recombinant protein of mouse full-length Ras homolog enriched in brain (Rheb), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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  • Gene Information
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Description : Activates the protein kinase activity of mTORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Has low intrinsic GTPase activity.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 20.5 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Rheb Ras homolog enriched in brain [ Mus musculus (house mouse) ]
Official Symbol : Rheb
Synonyms : RHEB; Ras homolog enriched in brain; GTP-binding protein Rheb; RAS-homolog enriched in brain
Gene ID : 19744
mRNA Refseq : NM_053075
Protein Refseq : NP_444305
UniProt ID : Q921J2

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does RHEB interact with the mTOR pathway, and what implications does this have for clinical interventions 05/29/2021

RHEB directly interacts with the mTOR pathway, a key regulator of cell growth. Understanding this interaction provides insights for developing drugs that target this pathway in diseases like cancer.

Are there any experimental drugs targeting RHEB currently in development? 01/15/2020

Some experimental drugs targeting RHEB are in preclinical development, showing promise in modulating cell growth and survival.

In what ways can the clinical application of RHEB be explored in cancer treatment? 04/24/2018

RHEB's involvement in cell growth makes it a potential target for cancer therapy. Understanding its role may lead to the development of targeted therapies.

Are there any ongoing clinical trials involving RHEB protein in cancer research? 02/18/2018

Research is underway to evaluate the therapeutic potential of targeting RHEB in cancer treatment, with several clinical trials exploring its role as a therapeutic target.

How does the dysregulation of RHEB contribute to diseases? 04/23/2017

Dysregulation of RHEB is associated with various diseases, including cancer and neurological disorders, due to its impact on cell growth and survival pathways.

Customer Reviews (3)

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Reviews
03/07/2020

    Researchers using RHEB protein can benefit from its high purity and quality, ensuring reliable results.

    05/24/2018

      the RHEB protein is available in different formats, including recombinant and purified variants.

      11/13/2017

        This flexibility allows researchers to select the most suitable form for their particular experimental setup, enhancing the efficiency and accuracy of their trials.

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