Recombinant Mouse Ror1 protein, His-tagged
Cat.No. : | Ror1-193M |
Product Overview : | Recombinant Mouse Ror1 (Gln30-Glu403) protein was fused to His-tag at C-terminus and expressed in human 293 cells (HEK293). |
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Description : | Tyrosine-protein kinase transmembrane receptor ROR1 is also known as Neurotrophic tyrosine kinase, receptor-related 1 (NTRKR1), which belongs to the protein kinase superfamily or tyr protein kinase family or ROR subfamily. ROR1 contains 1 FZ (frizzled) domain, 1 Ig-like C2-type (immunoglobulin-like) domain, 1 kringle domain, 1 protein kinase domain. ROR1 is expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm. ROR1 could interact with casein kinase 1 epsilon (CK1ε) to activate phosphoinositide 3-kinase-mediated AKT phosphorylation and cAMP-response-element-binding protein (CREB), which was associated with enhanced tumor-cell growth. |
Source : | HEK293 |
Species : | Mouse |
Tag : | His |
Predicted N Terminal : | Gln30 |
Form : | Lyophilized from 0.22 μm filtered solution in PBS, pH7.4, 10% trehalose. |
Molecular Mass : | The protein has a calculated MW of 42.6 kDa. The protein migrates as 60-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Protein length : | Gln30-Glu403 |
Endotoxin : | Less than 0.1 EU per μg by the LAL method. |
Purity : | >95% as determined by SDS-PAGE. |
Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20 to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Gene Name : | Ror1 |
Official Symbol : | Ror1 |
Synonyms : | ROR1; receptor tyrosine kinase-like orphan receptor 1; tyrosine-protein kinase transmembrane receptor ROR1; neurotrophic tyrosine kinase, receptor related 1; neurotrophic tyrosine kinase, receptor-related 1; mRor1; Ntrkr1; 2810404D04Rik |
Gene ID : | 26563 |
mRNA Refseq : | NM_013845 |
Protein Refseq : | NP_038873 |
UniProt ID : | Q9Z139 |
Products Types
◆ Recombinant Protein | ||
ROR1-429H | Recombinant Full Length Human ROR1 Protein, Fc-tagged | +Inquiry |
Ror1-5572M | Recombinant Mouse Ror1 Protein, Myc/DDK-tagged | +Inquiry |
Ror1-431M | Recombinant Full Length Mouse Ror1 Protein, Fc-tagged | +Inquiry |
ROR1-7706M | Recombinant Mouse ROR1 Protein, His (Fc)-Avi-tagged | +Inquiry |
ROR1-595H | Recombinant Human ROR1 Protein (Met1-Glu403), Biotinylated | +Inquiry |
◆ Lysates | ||
ROR1-001HCL | Recombinant Human ROR1 cell lysate | +Inquiry |
ROR1-002HCL | Recombinant Human ROR1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewCustomer service promptly feedback my requests, technical staff timely solve the problems that arise.
Excellent after-sales service, solving many experimental problems.
Fast and timely shipment helped me to get satisfactory experimental results in short time.
Q&As (4)
Ask a questionROR1 is barely expressed in normal, differentiated and mature tissues, but is highly expressed in tumor tissues.
Inhibit the expression of ROR1 can reduce the proliferation and migration ability of tumor cells.
ROR1 is involved in the regulation of cell metabolism, proliferation, apoptosis, and differentiation.
ROR1 is involved in the study of breast, lung and ovarian cancers.
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