Recombinant Mouse Scimp Protein, Myc/DDK-tagged

• Cat.No.: Scimp-5713M
• Product Overview: Purified recombinant protein of mouse full-length SLP adaptor and CSK interacting membrane protein (Scimp), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Lipid tetraspanin-associated transmembrane adapter/mediator that acts as a scaffold for Src-family kinases and other signaling proteins in immune cells. It is involved in major histocompatibility complex class II (MHC-II) signaling transduction in B cells, where it is required in generating the calcium response and enhancing ERK activity upon MHC-II stimulation. In dendritic cells, it is involved in sustaining CLEC7A/DECTIN1 signaling after CLEC7A activation by fungal beta-glucans. It also acts as an agonist-inducible signaling adapter for TLR1, TLR2, TLR3, TLR4, and TLR7 by selectively enabling the expression of pro-inflammatory cytokines IL6 and IL12B in macrophages and acting as a scaffold for phosphorylation of Toll-like receptors by Src-family kinases.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 17.1 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Scimp SLP adaptor and CSK interacting membrane protein [ Mus musculus (house mouse) ]
• Official Symbol: Scimp
• Synonyms: Scimp; SLP adaptor and CSK interacting membrane protein; A430084P05Rik; SLP adapter and CSK-interacting membrane protein; transmembrane protein C17orf87 homolog
• Gene ID: 327957
• mRNA Refseq: NM_001045526
• Protein Refseq: NP_001038991
• UniProt ID: Q3UU41