Active Recombinant Mouse Sema6a Protein, Fc-tagged
Cat.No. : | SEMA6A-14874M |
Product Overview : | Recombinant Mouse Sema 6A (Gly19-Thr649) Protein with Human IgG1 (Pro100-Lys330) tag was expressed in Spodoptera frugiperda, Sf 21. |
- Specification
- Gene Information
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Description : | Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an important role in axon guidance in the developing central nervous system. Can act as repulsive axon guidance cue. Has repulsive action towards migrating granular neurons. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation. |
Source : | Insect cell |
Species : | Mouse |
Tag : | Fc |
Predicted N Terminal : | Gly19 |
Bio-activity : | Measured by its ability to inhibit the proliferation of HUVEC human umbilical vein endothelial cells. The ED50 for this effect is 0.2-1.2 μg/mL. |
Molecular Mass : | 97 kDa |
Endotoxin : | < 0.1 EU/μg of the protein by the LAL method. |
Purity : | > 90% by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining. |
Storage : | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, -20 to -70 centigrade under sterile conditions after reconstitution. |
Storage Buffer : | Lyophilized from a 0.2 μm filtered solution in MES and NaCl with Trehalose. |
Reconstitution : | Reconstitute at 500 μg/mL in PBS. |
Shipping : | The product is shipped at ambient temperature. |
Gene Name : | Sema6a sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A [ Mus musculus (house mouse) ] |
Official Symbol : | Sema6a |
Synonyms : | Sema6a; sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A; se; Sem; VIa; Sema6; Semaq; b2b997C; AI851735; Sema6A-1; A730020P05Rik; semaphorin-6A; Mutant line 997; sema Q; sema VIA; semaphorin Q; semaphorin VIA; semaphorin-6A-1 |
Gene ID : | 20358 |
mRNA Refseq : | NM_018744 |
Protein Refseq : | NP_061214 |
UniProt ID : | O35464 |
Products Types
◆ Recombinant Protein | ||
SEMA6A-3885H | Recombinant Human SEMA6A protein, His-tagged | +Inquiry |
SEMA6A-10354Z | Recombinant Zebrafish SEMA6A | +Inquiry |
◆ Lysates | ||
SEMA6A-2081HCL | Recombinant Human SEMA6A cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionSEMA6A protein levels or mutations could potentially be used as a diagnostic marker for neurodevelopmental disorders.
The interaction partners of SEMA6A may serve as potential pharmacological targets for the development of drugs aimed at modulating neuronal development.
While SEMA6A's primary role is in neuronal development, there is emerging evidence suggesting its involvement in adult neuroplasticity and neural remodeling.
Research into the precise role of SEMA6A in autism may lead to the development of targeted therapies aimed at correcting neuronal development abnormalities.
SEMA6A is known to interact with other proteins involved in axon guidance and neuronal migration, contributing to the intricate network of molecular pathways in the developing brain.
Customer Reviews (3)
Write a reviewthe SEMA6A protein finds great utility in protein electron microscopy structure analysis, consistently delivering exceptional results.
Its remarkable sensitivity and specificity make it a valuable tool for accurate and robust data analysis, bolstering the credibility of research outcomes.
Notably, it exhibits exceptional performance in ELISA assays, providing reliable and precise results in the detection and quantification of target molecules.
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