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Active Recombinant Mouse Sema6a Protein, Fc-tagged

Cat.No. : SEMA6A-14874M
Product Overview : Recombinant Mouse Sema 6A (Gly19-Thr649) Protein with Human IgG1 (Pro100-Lys330) tag was expressed in Spodoptera frugiperda, Sf 21.
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Description : Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an important role in axon guidance in the developing central nervous system. Can act as repulsive axon guidance cue. Has repulsive action towards migrating granular neurons. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation.
Source : Insect cell
Species : Mouse
Tag : Fc
Predicted N Terminal : Gly19
Bio-activity : Measured by its ability to inhibit the proliferation of HUVEC human umbilical vein endothelial cells. The ED50 for this effect is 0.2-1.2 μg/mL.
Molecular Mass : 97 kDa
Endotoxin : < 0.1 EU/μg of the protein by the LAL method.
Purity : > 90% by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Storage : Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 centigrade as supplied.
1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
Storage Buffer : Lyophilized from a 0.2 μm filtered solution in MES and NaCl with Trehalose.
Reconstitution : Reconstitute at 500 μg/mL in PBS.
Shipping : The product is shipped at ambient temperature.
Gene Name : Sema6a sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A [ Mus musculus (house mouse) ]
Official Symbol : Sema6a
Synonyms : Sema6a; sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A; se; Sem; VIa; Sema6; Semaq; b2b997C; AI851735; Sema6A-1; A730020P05Rik; semaphorin-6A; Mutant line 997; sema Q; sema VIA; semaphorin Q; semaphorin VIA; semaphorin-6A-1
Gene ID : 20358
mRNA Refseq : NM_018744
Protein Refseq : NP_061214
UniProt ID : O35464

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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What are the potential diagnostic applications of SEMA6A protein? 07/04/2022

SEMA6A protein levels or mutations could potentially be used as a diagnostic marker for neurodevelopmental disorders.

Are there any known pharmacological targets related to SEMA6A protein? 02/15/2020

The interaction partners of SEMA6A may serve as potential pharmacological targets for the development of drugs aimed at modulating neuronal development.

Does SEMA6A protein have any role in adult neuroplasticity? 12/11/2019

While SEMA6A's primary role is in neuronal development, there is emerging evidence suggesting its involvement in adult neuroplasticity and neural remodeling.

Are there any therapeutic implications of SEMA6A protein in autism? 08/29/2018

Research into the precise role of SEMA6A in autism may lead to the development of targeted therapies aimed at correcting neuronal development abnormalities.

How does SEMA6A protein interact with other proteins in the brain? 05/21/2016

SEMA6A is known to interact with other proteins involved in axon guidance and neuronal migration, contributing to the intricate network of molecular pathways in the developing brain.

Customer Reviews (3)

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Reviews
01/22/2023

    the SEMA6A protein finds great utility in protein electron microscopy structure analysis, consistently delivering exceptional results.

    05/19/2022

      Its remarkable sensitivity and specificity make it a valuable tool for accurate and robust data analysis, bolstering the credibility of research outcomes.

      09/07/2016

        Notably, it exhibits exceptional performance in ELISA assays, providing reliable and precise results in the detection and quantification of target molecules.

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