Recombinant Mouse Sh2b2 Protein, Myc/DDK-tagged
Cat.No. : | Sh2b2-5833M |
Product Overview : | Purified recombinant protein of mouse full-length SH2B adaptor protein 2 (Sh2b2), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
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Description : | Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3. |
Source : | HEK293T |
Species : | Mouse |
Tag : | Myc/DDK |
Molecular Mass : | 66.6 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Sh2b2 SH2B adaptor protein 2 [ Mus musculus (house mouse) ] |
Official Symbol : | Sh2b2 |
Synonyms : | SH2B2; SH2B adaptor protein 2; SH2B adapter protein 2; insulin receptor substrate 5; SH2 and PH domain-containing adapter protein APS; adapter protein with pleckstrin homology and Src homology 2 domains; adaptor protein with pleckstrin homology and src homology 2 domains; Aps |
Gene ID : | 23921 |
mRNA Refseq : | NM_018825 |
Protein Refseq : | NP_061295 |
UniProt ID : | Q9JID9 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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