Recombinant Mouse Sh2d1a Protein, Myc/DDK-tagged

• Cat.No.: Sh2d1a-5834M
• Product Overview: Purified recombinant protein of mouse full-length SH2 domain containing 1A (Sh2d1a), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2. However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1. Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Can also promote CD48-, SLAMF6 -, LY9-, and SLAMF7-mediated NK cell activation. In the context of NK cell-mediated cytotoxicity enhances conjugate formation with target cells. May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 14.4 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Sh2d1a SH2 domain containing 1A [ Mus musculus (house mouse) ]
• Official Symbol: Sh2d1a
• Synonyms: SH2D1A; SH2 domain protein 1A; SH2 domain-containing protein 1A; Duncan disease homolog; SLAM-associated protein; T-cell signal transduction molecule SAP; signaling lymphocytic activation molecule-associated protein; SAP; Gm686
• Gene ID: 20400
• mRNA Refseq: NM_011364
• Protein Refseq: NP_035494
• UniProt ID: O88890