Recombinant Mouse Sh3kbp1 Protein, Myc/DDK-tagged

• Cat.No.: Sh3kbp1-5849M
• Product Overview: Purified recombinant protein of mouse full-length SH3-domain kinase binding protein 1 (Sh3kbp1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through an association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may be inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit. May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Has an essential role in the stimulation of B cell activation.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 73.8 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Sh3kbp1 SH3-domain kinase binding protein 1 [ Mus musculus (house mouse) ]
• Official Symbol: Sh3kbp1
• Synonyms: SH3KBP1; SH3-domain kinase binding protein 1; SH3 domain-containing kinase-binding protein 1; regulator of ubiquitous kinase; Sh3 containing, expressed in astrocytes; SH3-containing, expressed in tumorigenic astrocytes; Ruk; IN85; Seta; AI447724; 1200007H22Rik; 1700125L08Rik; 5830464D22Rik
• Gene ID: 58194
• mRNA Refseq: NM_001135727
• Protein Refseq: NP_001129199
• UniProt ID: Q8R550