Recombinant Mouse Slpi Protein, Myc/DDK-tagged

• Cat.No.: Slpi-5945M
• Product Overview: Purified recombinant protein of mouse full-length secretory leukocyte peptidase inhibitor (Slpi), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. Modulates the innate immune response after bacterial infection. Contributes to regulate the inflammatory and immune responses to the intracellular parasite L.major. Down-regulates responses to bacterial lipopolysaccharide (LPS). Plays a role in regulating the activation of NF-kappa-B and inflammatory responses. Has antimicrobial activity against mycobacteria, but not against salmonella. Contributes to normal resistance against infection by M.tuberculosis. Required for normal resistance to L.major. Required for normal wound healing, probably by preventing tissue damage by limiting protease activity. Together with ELANE, required for normal differentiation and proliferation of bone marrow myeloid cells.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 14.3 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Slpi secretory leukocyte peptidase inhibitor [ Mus musculus (house mouse) ]
• Official Symbol: Slpi
• Synonyms: SLPI; secretory leukocyte peptidase inhibitor; antileukoproteinase; ALP; secretory leukocyte protease inhibitor
• Gene ID: 20568
• mRNA Refseq: NM_011414
• Protein Refseq: NP_035544
• UniProt ID: P97430