Recombinant Mouse Smad4 Protein, Myc/DDK-tagged Smad4-5952M

Recombinant Mouse Smad4 Protein, Myc/DDK-tagged

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Cat.No. : Smad4-5952M Optional Service: Optional requirements on this protein
Product Overview : Purified recombinant protein of mouse full-length SMAD family member 4 (Smad4), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
Description : Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in response to TGF-beta. May act as a tumor suppressor. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions. In muscle physiology, plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 60.3 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Smad4 SMAD family member 4 [ Mus musculus (house mouse) ]
Official Symbol : Smad4
Synonyms : SMAD4; MAD homolog 4 (Drosophila); mothers against decapentaplegic homolog 4; Smad 4; SMAD family member 4; mothers against DPP homolog 4; deletion target in pancreatic carcinoma 4 homolog; DPC4; Madh4; AW743858; D18Wsu70e
Gene ID : 17128
mRNA Refseq : NM_008540
Protein Refseq : NP_032566
UniProt ID : P97471
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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