Recombinant Mouse Snx5 Protein, Myc/DDK-tagged

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Recombinant Mouse Snx5 Protein, Myc/DDK-tagged

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Cat.No. : Snx5-6036M
Product Overview : Purified recombinant protein of mouse full-length sorting nexin 5 (Snx5), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
Description : Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol lipids. Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC). Does not have in vitro vesicle-to-membrane remodeling activity. Involved in retrograde transport of lysosomal enzyme receptor IGF2R. May function as link between endosomal transport vesicles and dynactin. Plays a role in the internalization of EGFR after EGF stimulation. Involved in EGFR endosomal sorting and degradation; the function involves PIP5K1C and is retromer-independent. Together with PIP5K1C facilitates HGS interaction with ubiquitinated EGFR, which initiates EGFR sorting to intraluminal vesicles (ILVs) of the multivesicular body for subsequent lysosomal degradation. Involved in E-cadherin sorting and degradation; inhibits PIP5K1C-mediated E-cadherin degradation. Plays a role in macropinocytosis.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 46.8 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Snx5 sorting nexin 5 [ Mus musculus (house mouse) ]
Official Symbol : Snx5
Synonyms : SNX5; sorting nexin 5; sorting nexin-5; AU019504; D2Ertd52e; 0910001N05Rik; 1810032P22Rik
Gene ID : 69178
mRNA Refseq : NM_024225
Protein Refseq : NP_077187
UniProt ID : Q9D8U8
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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