Recombinant Mouse Tgfb2 Protein, Myc/DDK-tagged
Cat.No. : | Tgfb2-6389M |
Product Overview : | Purified recombinant protein of mouse full-length transforming growth factor, beta 2 (cDNA clone MGC:7998 IMAGE:3585774), complete cds, with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
- Specification
- Gene Information
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Description : | This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. Mice lacking a functional copy of this gene display developmental defects in multiple organs and perinatal lethality. Heterozygous mutant mice exhibit aortic root aneurysm. This gene encodes multiple isoforms that may undergo similar proteolytic processing. |
Source : | HEK293T |
Species : | Mouse |
Tag : | Myc/DDK |
Molecular Mass : | 29.1 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Tgfb2 transforming growth factor, beta 2 [ Mus musculus (house mouse) ] |
Official Symbol : | Tgfb2 |
Synonyms : | Tgfb2; transforming growth factor, beta 2; Tgfb-2; BB105277; Tgf-beta; Tgf-beta2; transforming growth factor beta-2 proprotein |
Gene ID : | 21808 |
mRNA Refseq : | NM_009367 |
Protein Refseq : | NP_033393 |
UniProt ID : | P27090 |
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◆ Lysates | ||
TGFB2-1119HCL | Recombinant Human TGFB2 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionIt can promote wound healing and tissue repair by stimulating the proliferation and migration of fibroblasts and epithelial cells, as well as promoting collagen synthesis.
Inhibitors or activators targeting TGFB2 may have potential applications for the treatment of a variety of diseases, including cancer, inflammatory diseases, autoimmune diseases, etc.
TGFB2 can regulate cell proliferation and differentiation by binding to its receptor and activating downstream signal transduction pathways.
This protein can be used as an immunomodulator to participate in the differentiation and function of immune cells, as well as the regulation of inflammatory responses.
The expression level of TGFB2 is regulated by a variety of factors, including transcription factors, signal transduction pathways, and epigenetic modifications.
TGFB2 has a variety of associations with other proteins and cytokines. For example, it may interact with vascular endothelial growth factor (VEGF) and be involved in angiogenesis, and may also interact with apoptosis-related proteins to regulate the apoptotic process.
Customer Reviews (3)
Write a reviewNo complicated experimental steps, suitable for beginners.
Excellent performance in Western blot, even if stored for a long time will not affect its performance.
The endotoxin levels were low enough not to interfere with the results.
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